Known targets — ChEMBL curated mechanism
ABL1BMXBRAFBTKCHRNA4CHRNB2CSNK1EEGFRERBB2F10FLT1FLT3FLT4IGF1RINSRITKJAK3KDRKITOPRM1PARP1PARP2PDGFRBPIK3CDRAF1RETSLC18A2TECTXKdacAdacBdacCftsImrcAmrcBmrdArplArplBrplCrplDrplErplFrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmFrpmGrpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of None. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADAM17 | P78536 | 5/20 | 0.63 |
| ▸ | UTS2R | Q9UKP6 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 14/20 | 0.33 |
| ▸ | MMP3 | P08254 | 10/20 | 0.33 |
| ▸ | MMP1 | P03956 | 9/20 | 0.33 |
| ▸ | MMP8 | P22894 | 5/20 | 0.33 |
| ▸ | MMP13 | P45452 | 4/20 | 0.33 |
| ▸ | MMP7 | P09237 | 6/20 | 0.33 |
| ▸ | MMP9 | P14780 | 6/20 | 0.33 |
| ▸ | MMP14 | P50281 | 2/20 | 0.33 |
| ▸ | MMP12 | P39900 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7102062 | 0.93 | ADAM17 (0.62) | ADAM17MMP2MMP3MMP1MMP8 | |
| SCHEMBL7103638 | 0.92 | ADAM17 (0.74) | ADAM17MMP2MMP3MMP1MMP8 | |
| SCHEMBL7103548 | 0.92 | ADAM17 (0.64) | ADAM17MMP2MMP3MMP1MMP8 | |
| SCHEMBL7104784 | 0.91 | ADAM17 (0.63) | ADAM17MMP2MMP3MMP1MMP8 | |
| SCHEMBL7100347 | 0.90 | ADAM17 (0.66) | ADAM17MMP2MMP3MMP1MMP8 | |
| SCHEMBL6985247 | 0.87 | ADAM17 (0.57) | ADAM17UTS2RMMP2MMP3MMP1 | |
| SCHEMBL7100103 | 0.84 | ADAM17 (0.71) | ADAM17MMP2MMP3MMP1MMP8 | |
| SCHEMBL7104655 | 0.83 | ADAM17 (0.75) | ADAM17MMP2MMP3MMP1MMP8 | |
| SCHEMBL6986624 | 0.83 | ADAM17 (0.60) | ADAM17MMP2MMP3MMP1MMP8 | |
| SCHEMBL7103556 | 0.82 | ADAM17 (0.74) | ADAM17MMP2MMP3MMP1MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1133471-B1 | HYDRAZINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2003-09-17 | — | — | EP | disclosed |
| US-6265446-B1 | ANTIINFLAMMATORY AGENTS; AUTOIMMUNE DISEASES | HOFFMANN-LA ROCHE INC.. | 2001-07-24 | — | — | US | disclosed |