Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.81 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.81 |
| ▸ | MEN1 | O00255 | 1/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.54 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.53 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.53 |
| ▸ | FNTA | P49354 | 1/20 | 0.51 |
| ▸ | FNTB | P49356 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.46 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | HTR1A | P08908 | 1/20 | 0.46 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.46 |
| ▸ | BCL2 | P10415 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | DRD1 | P21728 | 1/20 | 0.46 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.46 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1137956 | 0.90 | CYP2D6 (1.00) | CYP19A1CYP2D6MEN1KMT2AOPRD1 | |
| SCHEMBL3432555 | 0.88 | MEN1 (0.63) | CYP19A1CYP2D6MEN1KMT2AOPRD1 | |
| Norchlorcyclizine SCHEMBL7139140 | 0.84 | CYP2D6 (0.81) | CYP19A1CYP2D6MEN1KMT2AOPRD1 | |
| SCHEMBL11193886 | 0.84 | CYP2D6 (0.56) | CYP19A1CYP2D6MEN1KMT2AOPRD1 | |
| Norchlorcyclizine SCHEMBL588655 | 0.83 | CYP2D6 (0.86) | CYP19A1CYP2D6MEN1KMT2AOPRD1 | |
| Norchlorcyclizine SCHEMBL6556514 | 0.83 | CYP2D6 (0.86) | CYP19A1CYP2D6MEN1KMT2AOPRD1 | |
| Norchlorcyclizine SCHEMBL467086 | 0.83 | CYP2D6 (0.86) | CYP19A1CYP2D6MEN1KMT2AOPRD1 | |
| SCHEMBL5549076 | 0.83 | MEN1 (0.79) | CYP19A1CYP2D6MEN1KMT2AOPRD1 | |
| Norchlorcyclizine SCHEMBL588155 | 0.82 | CYP2D6 (0.83) | CYP19A1CYP2D6MEN1KMT2AOPRD1 | |
| Norchlorcyclizine SCHEMBL4649874 | 0.82 | CYP2D6 (0.83) | CYP19A1CYP2D6MEN1KMT2AOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020443-B1 | PROCESS FOR PRODUCING PIPERAZINESULFONAMIDE DERIVATIVES AND SALTS THEREOF | AZWELL INC (JP) | 2003-09-10 | — | — | EP | disclosed |
| US-6172228-B1 | Process for producing piperazinesulfonamide derivatives and salts thereof | AZWELL INC. (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-1020443-A1 | PROCESS FOR PRODUCING PIPERAZINESULFONAMIDE DERIVATIVES AND SALTS THEREOF | Azwell Inc. (JP) | 2000-07-19 | — | — | EP | disclosed |