Known targets — ChEMBL curated mechanism
ABL1ACEACHEACVR1ADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3AGTR1ALKAVPR1AAVPR2BCHEBCRCA2CACNA1ACACNA1BCACNA1CCACNA1DCACNA1ECACNA1FCACNA1GCACNA1HCACNA1ICACNA1SCACNA2D1CACNA2D2CACNA2D3CACNA2D4CACNB1CACNB2CACNB3CACNB4CACNG1CACNG2CACNG3CACNG4CACNG5CACNG6CACNG7CACNG8CALCRLCASRCCR5CDK4CDK6CFBCHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNA3CHRNA7CHRNB1CHRNB4CHRNDCHRNECHRNGCOXFA4COXFA4L2CRBNCSF1RCUL4ACYP19A1DDB1DPP4DRD1DRD2DRD3DRD4EDNRAEGFREML4ERBB2ERBB4ESR1ESR2FGFR1FGFR3FLT1FLT3FLT4GAAGABRA1GABRA2GABRA3GABRA4GABRA5GABRA6GABRB1GABRB2GABRB3GABRDGABREGABRG1GABRG2GABRG3GABRPGABRQGHSRGLAGNRHRGPD2GRIN1GRIN2AGRIN2BGRIN2CGRIN2DGRIN3AGRIN3BGSTP1HCN4HCRTR1HCRTR2HDAC1HDAC10HDAC11HDAC2HDAC3HDAC4HDAC5HDAC6HDAC7HDAC8HDAC9HRH1HRH2HRH3HSD11B1HSP90AA1HSP90AB1HTR1AHTR1BHTR1DHTR1EHTR1FHTR2AHTR2BHTR2CHTR3AHTR3BHTR3CHTR3DHTR3EHTR4HTR5AHTR6HTR7IMPDH1IMPDH2ITGA2BITGB3ITKJAK1JAK2KCNA1KCNA10KCNA2KCNA3KCNA4KCNA5KCNA6KCNA7KCNB1KCNB2KCNC1KCNC2KCNC3KCNC4KCND1KCND2KCND3KCNF1KCNG1KCNG2KCNG3KCNG4KCNH1KCNH2KCNH3KCNH4KCNH5KCNH6KCNH7KCNH8KCNJ2KCNJ3KCNJ5KCNK3KCNK9KCNQ1KCNQ2KCNQ3KCNQ4KCNQ5KCNS1KCNS2KCNS3KCNV1KCNV2KDRKITKLKB1LCKMMAOAMAOBMAPK14METMMP1MMP13MMP7MMP8MT-ND1MT-ND2MT-ND3MT-ND4MT-ND4LMT-ND5MT-ND6NDUFA1NDUFA10NDUFA11NDUFA12NDUFA13NDUFA2NDUFA3NDUFA5NDUFA6NDUFA7NDUFA8NDUFA9NDUFAB1NDUFAF1NDUFAF2NDUFAF3NDUFAF4NDUFB1NDUFB10NDUFB11NDUFB2NDUFB3NDUFB4NDUFB5NDUFB6NDUFB7NDUFB8NDUFB9NDUFC1NDUFC2NDUFS1NDUFS2NDUFS3NDUFS4NDUFS5NDUFS6NDUFS7NDUFS8NDUFV1NDUFV2NDUFV3NR3C1NS5ANTRK1NTRK2NTRK3ODC1OPRD1OPRK1OPRM1P2RY12PAHPARP1PDE3APDE3BPDE4APDE4BPDE4CPDE4DPDE5APDE7APDE7BPDE8APDE8BPDGFRAPDGFRBPIK3CAPIK3CDPNPPOLA1POLA2POLD1POLD2POLD3POLD4POLEPOLE2POLE3PPARGPRIM1PRIM2PRKCAPRKCBPRKCDPRKCEPRKCGPRKCHPRKCIPRKCQPRKCZPRKD1PRKD3PTGS1PTGS2RBX1RENRETROCK1ROCK2RPE65RRM1RRM2RRM2BS1PR1S1PR2S1PR3S1PR4S1PR5SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9ASCNN1ASCNN1BSCNN1GSIGMAR1SLC18A2SLC6A1SLC6A2SLC6A3SLC6A4SLC9A3SRCTACR1TOP1TOP2ATOP2BTTRTYMPdacAdacBdacCembAfolAftsIgyrAgyrBmrcAmrcBmrdAparCparEpolrplArplBrplCrplDrplErplFrplIrplJrplKrplLrplMrplNrplOrplPrplQrplRrplSrplTrplUrplVrplWrplXrplYrpmArpmBrpmCrpmDrpmErpmE2rpmFrpmGrpmG1rpmG2rpmG3rpmHrpmIrpmJrpsArpsBrpsCrpsDrpsErpsFrpsGrpsHrpsIrpsJrpsKrpsLrpsMrpsNrpsOrpsPrpsQrpsRrpsSrpsTrpsUykgMykgO
The experimentally established mechanism targets of Norchlorcyclizine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 known ✓ | P11511 | 1/20 | 0.83 |
| ▸ | OPRD1 known ✓ | P41143 | 10/20 | 0.65 |
| ▸ | CHRM2 known ✓ | P08172 | 2/20 | 0.64 |
| ▸ | HTR1A known ✓ | P08908 | 2/20 | 0.64 |
| ▸ | ADRA2A known ✓ | P08913 | 2/20 | 0.64 |
| ▸ | CHRM1 known ✓ | P11229 | 2/20 | 0.64 |
| ▸ | DRD1 known ✓ | P21728 | 2/20 | 0.64 |
| ▸ | SLC6A2 known ✓ | P23975 | 2/20 | 0.64 |
| ▸ | SLC6A4 known ✓ | P31645 | 2/20 | 0.64 |
| ▸ | ADRA1A known ✓ | P35348 | 2/20 | 0.64 |
| ▸ | DRD3 known ✓ | P35462 | 2/20 | 0.64 |
| ▸ | SLC6A3 known ✓ | Q01959 | 2/20 | 0.64 |
| ▸ | KCNH2 known ✓ | Q12809 | 2/20 | 0.64 |
| ▸ | HRH3 known ✓ | Q9Y5N1 | 1/20 | 0.64 |
| ▸ | OPRM1 known ✓ | P35372 | 2/20 | 0.57 |
| ▸ | OPRK1 known ✓ | P41145 | 1/20 | 0.56 |
| ▸ | CACNA1A known ✓ | O00555 | 1/20 | 0.55 |
| ▸ | CACNA2D1 known ✓ | P54289 | 1/20 | 0.55 |
| ▸ | CACNB1 known ✓ | Q02641 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.83 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Norchlorcyclizine SCHEMBL588155 | 1.00 | CYP2D6 (0.83) | CYP2D6CYP19A1MEN1KMT2ACYP2C19 | |
| Norchlorcyclizine SCHEMBL6556514 | 0.98 | CYP2D6 (0.86) | CYP2D6CYP19A1MEN1KMT2ACYP2C19 | |
| Norchlorcyclizine SCHEMBL467086 | 0.98 | CYP2D6 (0.86) | CYP2D6CYP19A1MEN1KMT2ACYP2C19 | |
| Norchlorcyclizine SCHEMBL588655 | 0.98 | CYP2D6 (0.86) | CYP2D6CYP19A1MEN1KMT2ACYP2C19 | |
| Norchlorcyclizine SCHEMBL7139140 | 0.95 | CYP2D6 (0.81) | CYP2D6CYP19A1MEN1KMT2ACYP2C19 | |
| Norchlorcyclizine SCHEMBL7993069 | 0.93 | CYP2D6 (0.71) | CYP2D6CYP19A1MEN1KMT2ACYP2C19 | |
| SCHEMBL5363117 | 0.92 | CYP2D6 (0.76) | CYP2D6CYP19A1MEN1KMT2ACYP2C19 | |
| SCHEMBL1137956 | 0.91 | CYP2D6 (1.00) | CYP2D6CYP19A1MEN1KMT2ACYP2C19 | |
| Norchlorcyclizine SCHEMBL7989800 | 0.91 | CYP2D6 (0.69) | CYP2D6CYP19A1MEN1KMT2ACYP2C19 | |
| Norchlorcyclizine SCHEMBL7989702 | 0.91 | CYP2D6 (0.73) | CYP2D6CYP19A1MEN1KMT2ACYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1963296-A2 | OPTICALLY ACTIVE CARBAMATES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS PHARMACEUTICAL INTERMEDIATES | Egis Gyógyszergyár Nyilvánosan Múködö Részvénytársaság (HU) | 2008-09-03 | — | — | EP | disclosed |
| EP-1874364-A2 | SUPERABSORBER TREATED WITH METALLIC SALT AND METALLIC OXIDE AND POST-CROSSLINKED ON THE SURFACE THEREOF | Evonik Stockhausen GmbH (DE) | 2008-01-09 | — | — | EP | disclosed |
| WO-2007066163-A2 | OPTICALLY ACTIVE CARBAMATES, PROCESS FOR PREPARATION THEREOF AND USE THEREOF AS PHARMACEUTICAL INTERMEDIATES | Egis Gyógyszergyár Nyilvanosan Mukodo Reszvenytarsasag (HU) | 2007-06-14 | — | — | WO | disclosed |
| WO-2006111402-A2 | SUPERABSORBER TREATED WITH METALLIC SALT AND METALLIC OXIDE AND POST-CROSSLINKED ON THE SURFACE THEREOF | EVONIK STOCKHAUSEN GMBH (DE) | 2006-10-26 | — | — | WO | disclosed |
| EP-1236722-B1 | Optically active 4-(tert-butoxycarbonyl) piperazine compound, and method for producing the same | SUMITOMO CHEMICAL CO (JP) | 2006-04-19 | — | — | EP | disclosed |
| US-6803465-B2 | INTERMEDIATES FOR THE PRODUCTION OF ANTIALLERGIC PHARMACEUTICALS | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2004-10-12 | — | — | US | disclosed |
| US-20020128275-A1 | Optically active 4-(tert-butoxycarbonyl)piperazine compound, and method for producing the same | SUMITOMO CHEMICAL COMPANY, LIMITED | 2002-09-12 | — | — | US | disclosed |
| EP-1236722-A1 | Optically active 4-(tert-butoxycarbonyl) piperazine compound, and method for producing the same | SUMITOMO CHEMICAL COMPANY, LIMITED (JP) | 2002-09-04 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128275-A1 | Optically active 4-(tert-butoxycarbonyl)piperazine compound, and method for producing the same | TERT, TTI1, TBC1D15 | CYP19A1 86/4885OPRD1 1514/4885CHRM2 2464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.