Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | KDM6B | O15054 | 1/20 | 0.34 |
| ▸ | KDM6A | O15550 | 1/20 | 0.34 |
| ▸ | TET3 | O43151 | 1/20 | 0.34 |
| ▸ | KDM4A | O75164 | 1/20 | 0.34 |
| ▸ | KDM4B | O94953 | 1/20 | 0.34 |
| ▸ | KDM5C | P41229 | 1/20 | 0.34 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.34 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.34 |
| ▸ | ALKBH5 | Q6P6C2 | 1/20 | 0.34 |
| ▸ | TET1 | Q8NFU7 | 1/20 | 0.34 |
| ▸ | FTO | Q9C0B1 | 1/20 | 0.34 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.34 |
| ▸ | KDM2A | Q9Y2K7 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KDM3A | Q9Y4C1 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4064159 | 0.89 | GLO1 (0.41) | KMT2AMEN1GLO1KDM4ECOMT | |
| SCHEMBL4059970 | 0.83 | CALCA (0.49) | KMT2AMEN1GLO1POLB | |
| SCHEMBL4076247 | 0.81 | KDM4E (0.41) | KMT2AMEN1KDM4EKDM6BKDM6A | |
| SCHEMBL4769298 | 0.79 | COMT (0.40) | KMT2AKDM4EKDM6BKDM6ATET3 | |
| SCHEMBL4059699 | 0.78 | ADORA2A (0.39) | GLO1L3MBTL1COMT | |
| SCHEMBL4060218 | 0.77 | CALCA (0.38) | GLO1L3MBTL1COMT | |
| SCHEMBL4072643 | 0.69 | KDM4E (0.44) | KMT2AKDM4EEGLN1L3MBTL1COMT | |
| SCHEMBL7258791 | 0.68 | KDM4E (0.45) | KMT2AMEN1KDM4EKDM6BKDM6A | |
| SCHEMBL7258267 | 0.68 | KDM4E (0.53) | KMT2AMEN1GLO1KDM4EKDM6B | |
| SCHEMBL7101457 | 0.68 | TDP1 (0.42) | KMT2AMEN1GLO1KDM4EFTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326865-A2 | AZA- AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2003-07-16 | — | — | EP | disclosed |
| WO-2002030930-A2 | AZA- AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2002-04-18 | — | — | WO | disclosed |