Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CALCA | P06881 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.40 |
| ▸ | CCR1 | P32246 | 1/20 | 0.40 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7095564 | 0.88 | CALCA (0.40) | CALCAKDM4ETDP1 | |
| SCHEMBL7101457 | 0.83 | TDP1 (0.42) | SMN1; SMN2KMT2AKDM4EMEN1TDP1 | |
| SCHEMBL4064102 | 0.79 | CALCA (0.58) | CALCASMN1; SMN2KMT2A | |
| SCHEMBL13812901 | 0.78 | CALCA (0.57) | CALCASMN1; SMN2KMT2A | |
| SCHEMBL6504246 | 0.77 | CALCA (0.60) | CALCASMN1; SMN2KMT2A | |
| SCHEMBL6490436 | 0.75 | CALCA (0.62) | CALCASMN1; SMN2KMT2A | |
| SCHEMBL4059970 | 0.75 | CALCA (0.49) | CALCASMN1; SMN2KMT2AMEN1 | |
| SCHEMBL4060740 | 0.74 | CALCA (0.61) | CALCASMN1; SMN2KMT2A | |
| SCHEMBL4058930 | 0.74 | CALCA (0.69) | CALCASMN1; SMN2KMT2A | |
| SCHEMBL7101920 | 0.73 | CALCA (0.60) | CALCASMN1; SMN2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1326865-A2 | AZA- AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | Merck & Co., Inc. (US) | 2003-07-16 | — | — | EP | claimed |
| WO-2002030930-A2 | AZA- AND POLYAZA-NAPHTHALENYL CARBOXAMIDES USEFUL AS HIV INTEGRASE INHIBITORS | MERCK & CO., INC. (US) | 2002-04-18 | — | — | WO | claimed |