Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EYA3 | Q99504 | 6/20 | 0.71 |
| ▸ | TTR | P02766 | 4/20 | 0.69 |
| ▸ | MEN1 | O00255 | 2/20 | 0.69 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 2/20 | 0.69 |
| ▸ | PGR | P06401 | 2/20 | 0.69 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.69 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.69 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.69 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | BIRC5 | O15392 | 1/20 | 0.69 |
| ▸ | HTR1A | P08908 | 1/20 | 0.69 |
| ▸ | DRD1 | P21728 | 1/20 | 0.69 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.69 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.69 |
| ▸ | PDE4A | P27815 | 1/20 | 0.69 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.69 |
| ▸ | DRD3 | P35462 | 1/20 | 0.69 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7750214 | 0.85 | EYA3 (0.66) | EYA3TTRMEN1ABCB11LMNA | |
| SCHEMBL7752224 | 0.85 | EYA3 (0.74) | EYA3TTRMEN1ABCB11LMNA | |
| SCHEMBL6335384 | 0.83 | EYA3 (1.00) | EYA3TTRMEN1ABCB11LMNA | |
| Benziodarone SCHEMBL31326233 | 0.82 | EYA3 (1.00) | EYA3TTRMEN1ABCB11LMNA | |
| Benziodarone SCHEMBL308541 | 0.82 | EYA3 (1.00) | EYA3TTRMEN1ABCB11LMNA | |
| SCHEMBL9162004 | 0.82 | KDM5A (0.76) | MEN1ABCB11LMNAADRA2AOPRM1 | |
| SCHEMBL25393114 | 0.82 | EYA3 (0.73) | EYA3TTRMEN1ABCB11LMNA | |
| SCHEMBL25047095 | 0.81 | EYA3 (0.91) | EYA3TTRMEN1ABCB11LMNA | |
| SCHEMBL25390721 | 0.81 | EYA3 (0.91) | EYA3TTRMEN1ABCB11LMNA | |
| SCHEMBL25389973 | 0.80 | EYA3 (0.85) | EYA3TTRMEN1ABCB11LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2002038557-A9 | BENZOYLBENZOFURANE DERIVATIVES FOR TREATMENT OF CARDIAC ARRHYTHMIA | ARYX THERAPEUTICS (US) | 2003-09-18 | — | — | WO | disclosed |
| US-6316487-B1 | FOR THERAPY OF VENTRICULAR TACHYARRHYTHMIAS, ESPECIALLY IN PATIENTS WITH CONGESTIVE HEART FAILURE AND VENTRICULAR ARRHYTHMIAS AND SUPRAVENTRICULAR ARRHYTHMIAS, INCLUDING ATRIAL FIBRILLATION AND RE-ENTRANT TACHYARRHYTHMIAS | ARYX THERAPEUTICS | 2001-11-13 | — | — | US | disclosed |