Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNB2 | P17787 | 3/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 3/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | PIP5K1C | O60331 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.36 |
| ▸ | PI4KA | P42356 | 1/20 | 0.36 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.36 |
| ▸ | AKT1 | P31749 | 1/20 | 0.35 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.35 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.34 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.34 |
| ▸ | CHRNB3 | Q05901 | 1/20 | 0.34 |
| ▸ | CHRNA6 | Q15825 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7238338 | 0.80 | CHRNB2 (0.41) | CHRNB2CHRNA4PIK3CDPIP5K1CPIK3CA | |
| SCHEMBL27599231 | 0.78 | CHRNB2 (0.49) | CHRNB2CHRNA4PIK3CDPIP5K1CPIK3CA | |
| SCHEMBL7104153 | 0.78 | AKT1 (0.44) | CHRNB2CHRNA4AKT1CHRNB4CHRNA3 | |
| SCHEMBL7101816 | 0.76 | KDM4E (0.58) | CHRNB2CHRNA4CHRNB4CHRNA3 | |
| SCHEMBL23917658 | 0.76 | CHRNB2 (0.36) | CHRNB2CHRNA4TDP1PIK3CDPIP5K1C | |
| SCHEMBL25623895 | 0.73 | CHRNB2 (0.36) | CHRNB2CHRNA4PIK3CDPIP5K1CPIK3CA | |
| SCHEMBL14396218 | 0.72 | CHRNB2 (0.60) | CHRNB2CHRNA4 | |
| SCHEMBL12925127 | 0.71 | CYP1A1 (0.47) | CHRNB2CHRNA4PIK3CDPIP5K1CPIK3CA | |
| SCHEMBL3940185 | 0.70 | PIK3CD (0.46) | CHRNB2CHRNA4PIK3CDPIP5K1CPIK3CA | |
| SCHEMBL25637548 | 0.69 | TDP1 (0.46) | CHRNB2CHRNA4TDP1CHRNB4CHRNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003500393-A | — | — | 2003-01-07 | — | — | JP | claimed |
| EP-1185513-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2002-03-13 | — | — | EP | claimed |
| WO-2000071520-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2000-11-30 | — | — | WO | claimed |