Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AKT1 | P31749 | 5/20 | 0.44 |
| ▸ | MAOB | P27338 | 3/20 | 0.44 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.42 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.42 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.42 |
| ▸ | PIM1 | P11309 | 1/20 | 0.42 |
| ▸ | PRKACA | P17612 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | CLK2 | P49760 | 1/20 | 0.42 |
| ▸ | GSK3A | P49840 | 1/20 | 0.42 |
| ▸ | GSK3B | P49841 | 1/20 | 0.42 |
| ▸ | PRKX | P51817 | 1/20 | 0.42 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.42 |
| ▸ | PRKG2 | Q13237 | 1/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.42 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.42 |
| ▸ | CDC42BPA | Q5VT25 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8512404 | 0.82 | MAOB (0.56) | MAOBPDGFRBPDGFRARAB9ASMN1; SMN2 | |
| SCHEMBL13535019 | 0.81 | AOC3 (0.54) | MAOBAOC3PDGFRBPDGFRACHRNB2 | |
| SCHEMBL7522249 | 0.80 | AKT1 (0.50) | AKT1MAOBROCK2MAP4K4PIM1 | |
| SCHEMBL6584828 | 0.80 | MAOB (0.53) | MAOBPDGFRBPDGFRACHRNB2CHRNB4 | |
| SCHEMBL7101811 | 0.78 | CHRNB2 (0.40) | AKT1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL7237701 | 0.78 | MAOB (0.46) | MAOBPDGFRBPDGFRARAB9ASMN1; SMN2 | |
| SCHEMBL4538153 | 0.77 | MAOB (0.67) | MAOBPDGFRBPDGFRAMAPTMEN1 | |
| SCHEMBL6584825 | 0.77 | MAOB (0.50) | AKT1MAOBROCK2RPS6KA5MAP4K4 | |
| SCHEMBL20729413 | 0.77 | ALOX5 (0.47) | MAOBPDGFRBPDGFRARAB9ASMN1; SMN2 | |
| SCHEMBL7103954 | 0.76 | HTR1B (0.57) | MAOBCHRNB2CHRNA4LTA4HSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003500393-A | — | — | 2003-01-07 | — | — | JP | claimed |
| EP-1185513-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | Targacept, Inc. (US) | 2002-03-13 | — | — | EP | claimed |
| WO-2000071520-A2 | ARYL SUBSTITUTED ALKYLAMINES CAPABLE OF ACTIVATING NICOTINIC CHOLINERGIC RECEPTORS | TARGACEPT, INC. (US) | 2000-11-30 | — | — | WO | claimed |