Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.51 |
| ▸ | SLC6A4 | P31645 | 4/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.48 |
| ▸ | OPRD1 | P41143 | 7/20 | 0.48 |
| ▸ | TACR1 | P25103 | 4/20 | 0.44 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7101323 | 0.84 | MEN1 (0.58) | MEN1KMT2ACYP2D6CYP19A1SLC6A4 | |
| SCHEMBL8694125 | 0.81 | MEN1 (0.67) | MEN1KMT2ASLC6A4SLC6A2OPRD1 | |
| SCHEMBL6580465 | 0.80 | CYP2D6 (0.65) | MEN1KMT2ACYP2D6CYP19A1SLC6A4 | |
| SCHEMBL7098971 | 0.79 | MEN1 (0.72) | MEN1KMT2ACYP2D6CYP19A1SLC6A4 | |
| Norchlorcyclizine SCHEMBL7139140 | 0.77 | CYP2D6 (0.81) | MEN1KMT2ACYP2D6CYP19A1SLC6A4 | |
| SCHEMBL1741576 | 0.77 | MEN1 (0.74) | MEN1KMT2ACYP2D6CYP19A1SLC6A4 | |
| Norchlorcyclizine SCHEMBL6556514 | 0.76 | CYP2D6 (0.86) | MEN1KMT2ACYP2D6CYP19A1SLC6A4 | |
| Norchlorcyclizine SCHEMBL588655 | 0.76 | CYP2D6 (0.86) | MEN1KMT2ACYP2D6CYP19A1SLC6A4 | |
| Norchlorcyclizine SCHEMBL467086 | 0.76 | CYP2D6 (0.86) | MEN1KMT2ACYP2D6CYP19A1SLC6A4 | |
| SCHEMBL2794662 | 0.75 | MEN1 (1.00) | MEN1KMT2ACYP2D6CYP19A1SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1020443-B1 | PROCESS FOR PRODUCING PIPERAZINESULFONAMIDE DERIVATIVES AND SALTS THEREOF | AZWELL INC (JP) | 2003-09-10 | — | — | EP | disclosed |
| US-6172228-B1 | Process for producing piperazinesulfonamide derivatives and salts thereof | AZWELL INC. (JP) | 2001-01-09 | — | — | US | disclosed |
| EP-1020443-A1 | PROCESS FOR PRODUCING PIPERAZINESULFONAMIDE DERIVATIVES AND SALTS THEREOF | Azwell Inc. (JP) | 2000-07-19 | — | — | EP | disclosed |