Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGA4 | P13612 | 1/20 | 0.58 |
| ▸ | NAPEPLD | Q6IQ20 | 1/20 | 0.58 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.44 |
| ▸ | ESR1 | P03372 | 4/20 | 0.43 |
| ▸ | ESR2 | Q92731 | 3/20 | 0.43 |
| ▸ | ATM | Q13315 | 2/20 | 0.43 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.42 |
| ▸ | TUBB | P07437 | 1/20 | 0.42 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.42 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.42 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.42 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.42 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.42 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.42 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.42 |
| ▸ | TUBA3E | Q6PEY2 | 1/20 | 0.42 |
| ▸ | TUBA1A | Q71U36 | 1/20 | 0.42 |
| ▸ | TUBA1C | Q9BQE3 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7106095 | 0.92 | TUBB4A (0.51) | ITGA4NAPEPLDHCRTR1L3MBTL1ESR1 | |
| SCHEMBL7106562 | 0.89 | ITGA4 (0.58) | ITGA4NAPEPLDHCRTR1L3MBTL1PAX8 | |
| SCHEMBL7108616 | 0.85 | ITGA4 (0.51) | ITGA4NAPEPLDHCRTR1L3MBTL1PAX8 | |
| SCHEMBL7106045 | 0.85 | ITGA4 (0.53) | ITGA4NAPEPLDHCRTR1L3MBTL1ESR1 | |
| SCHEMBL7101221 | 0.83 | ESR1 (0.66) | ITGA4ESR1ESR2UBE2N | |
| SCHEMBL7108339 | 0.83 | ESR1 (0.61) | ITGA4NAPEPLDESR1ESR2ALDH1A1 | |
| SCHEMBL7101025 | 0.83 | ITGA4 (0.51) | ITGA4NAPEPLDHCRTR1L3MBTL1PAX8 | |
| SCHEMBL7101796 | 0.83 | ESR1 (0.50) | ITGA4NAPEPLDL3MBTL1ESR1ESR2 | |
| Hydrochloric Acid SCHEMBL7103199 | 0.82 | ESR1 (0.65) | ITGA4ESR1ESR2UBE2N | |
| SCHEMBL17155697 | 0.82 | TUBB4A (0.63) | ESR1ESR2TUBB4ATUBBTUBA3C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0827959-B1 | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | disclosed |
| US-5977382-A | Benzo[b]thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| US-5977098-A | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| EP-0827959-A2 | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-03-11 | — | — | EP | disclosed |