SCHEMBL7102124

SCHEMBL7102124

CNN1CC[C@@H](c2cnc(Br)c(Cl)c2)C1

nearest known ligand 0.35

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.35
CHRNA4 P43681 2/20 0.35
CHRNB4 P30926 1/20 0.35
CHRNA3 P32297 1/20 0.35
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33
KCNH2 Q12809 1/20 0.33
SPR P35270 2/20 0.32
NPC1 O15118 1/20 0.31
NFKB1 P19838 1/20 0.31
RAB9A P51151 1/20 0.31
NFKB2 Q00653 1/20 0.31
RELA Q04206 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
HRH4 Q9H3N8 1/20 0.30
HRH3 Q9Y5N1 1/20 0.30
EGLN1 Q9GZT9 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7098864 1.00 CHRNB2 (0.35) CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2
SCHEMBL7101551 0.92 SLC6A2 (0.36) CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2
SCHEMBL7100533 0.92 SLC6A2 (0.36) CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2
SCHEMBL7102133 0.91 SLC6A2 (0.41) CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2
SCHEMBL7102607 0.91 SLC6A2 (0.41) CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2
SCHEMBL7101259 0.87 CHRNB2 (0.35) CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2
SCHEMBL7103819 0.87 CHRNB2 (0.35) CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2
SCHEMBL7105235 0.86 CHRNB2 (0.36) CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2
SCHEMBL7098850 0.86 CHRNB2 (0.36) CHRNB2CHRNA4CHRNB4CHRNA3SLC6A2
SCHEMBL7098393 0.85 ALDH1A1 (0.40) CHRNB2CHRNA4SPREGLN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2003500402-A 2003-01-07 JP claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP claimed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP disclosed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO disclosed