Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNA2 | P20248 | 8/20 | 0.38 |
| ▸ | CDK2 | P24941 | 8/20 | 0.38 |
| ▸ | CCNA1 | P78396 | 8/20 | 0.38 |
| ▸ | CDK5 | Q00535 | 8/20 | 0.38 |
| ▸ | DYRK1A | Q13627 | 8/20 | 0.38 |
| ▸ | CDK5R1 | Q15078 | 8/20 | 0.38 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.38 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.38 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7104801 | 0.89 | ADORA2A (0.43) | CCNA2CDK2CCNA1CDK5DYRK1A | |
| SCHEMBL7151509 | 0.89 | ADORA2A (0.43) | CCNA2CDK2CCNA1CDK5DYRK1A | |
| SCHEMBL7208763 | 0.86 | CCNA2 (0.39) | CCNA2CDK2CCNA1CDK5DYRK1A | |
| SCHEMBL7102240 | 0.81 | ADORA2A (0.39) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL7103750 | 0.77 | ADORA2A (0.51) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL6574865 | 0.76 | ADORA1 (0.47) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL7574648 | 0.76 | ADORA2A (0.44) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL7211360 | 0.76 | ADORA2A (0.43) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL7099680 | 0.76 | ADORA1 (0.57) | ADORA2AADORA2BADORA3ADORA1 | |
| SCHEMBL7566398 | 0.76 | ADORA1 (0.47) | CDK5ADORA2AADORA2BADORA3ADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090023-B1 | 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2003-09-10 | — | — | EP | disclosed |