Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 4/20 | 0.59 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.59 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.59 |
| ▸ | NT5E | P21589 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8325836 | 0.88 | ADORA2A (0.75) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL1415120 | 0.88 | ADORA2A (0.75) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL1415110 | 0.88 | ADORA2A (0.75) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL1415112 | 0.88 | ADORA2A (0.75) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL1415122 | 0.88 | ADORA2A (0.75) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL7098149 | 0.85 | ADORA3 (0.48) | ADORA2AADORA1ADORA3ADORA2BNT5E | |
| SCHEMBL10689350 | 0.84 | ADORA2A (0.68) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL10689357 | 0.84 | ADORA2A (0.68) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL7102409 | 0.83 | ADORA2A (0.71) | ADORA2AADORA1ADORA3ADORA2B | |
| SCHEMBL7102408 | 0.83 | ADORA2A (0.71) | ADORA2AADORA1ADORA3ADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1090021-B1 | 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LTD (GB) | 2003-09-10 | — | — | EP | disclosed |
| US-6534486-B1 | With broad anti-inflammatory properties which inhibit leukocyte recruitment and activation and which are agonists of the adenosine 2a receptor are described. | SMITHKLINE BEECHAM CORPORATION | 2003-03-18 | — | — | US | disclosed |
| EP-1090021-A1 | 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 2001-04-11 | — | — | EP | disclosed |
| WO-1999067266-A1 | 2-(PURIN-9-YL)-TETRAHYDROFURAN-3,4-DIOL DERIVATIVES | GLAXO GROUP LIMITED (GB) | 1999-12-29 | — | — | WO | disclosed |