Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 7/20 | 0.40 |
| ▸ | RAB9A | P51151 | 7/20 | 0.40 |
| ▸ | MAPT | P10636 | 5/20 | 0.40 |
| ▸ | BCHE | P06276 | 3/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.38 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.38 |
| ▸ | RELA | Q04206 | 1/20 | 0.38 |
| ▸ | AKT1 | P31749 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | PKM | P14618 | 3/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28150514 | 0.84 | NPC1 (0.43) | NPC1RAB9AMAPTBCHELMNA | |
| SCHEMBL4620579 | 0.72 | MAOB (0.46) | NPC1RAB9AMAPTBCHELMNA | |
| SCHEMBL27741901 | 0.70 | NPC1 (0.40) | NPC1RAB9AMAPTBCHELMNA | |
| SCHEMBL12484187 | 0.70 | RECQL (0.40) | NPC1RAB9AMAPTBCHELMNA | |
| SCHEMBL15058526 | 0.68 | AKT1 (0.38) | NPC1RAB9AMAPTBCHELMNA | |
| SCHEMBL17318505 | 0.68 | AKT1 (0.38) | NPC1RAB9AMAPTBCHELMNA | |
| SCHEMBL27741902 | 0.67 | BCHE (0.39) | NPC1RAB9AMAPTBCHELMNA | |
| SCHEMBL28776174 | 0.67 | NPC1 (0.39) | NPC1RAB9AMAPTBCHELMNA | |
| SCHEMBL5287718 | 0.66 | MAPT (0.41) | NPC1RAB9AMAPTBCHELMNA | |
| SCHEMBL8845815 | 0.66 | RECQL (0.45) | NPC1RAB9AMAPTBCHELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003097577-A1 | CHEMICAL COMPOUND CONSISTING OF A NITROGENOUS CHALCONE DERIVATIVE, METHOD OF PRODUCING ONE SUCH CHEMICAL COMPOUND AND FILTERING AND/OR COSMETIC COMPOSITION CONTAINING SAME | SYNTH'E163 (SOCIETE ANONYME) (FR) | 2003-11-27 | — | — | WO | disclosed |