Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | PRNP | P04156 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | PPARG | P37231 | 1/20 | 0.50 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.50 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.50 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7107233 | 0.83 | HSP90AA1 (0.53) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL7936769 | 0.78 | MAPT (0.59) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL7106224 | 0.77 | MAPT (0.55) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL24703043 | 0.77 | MAPT (0.47) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL7104829 | 0.77 | HSP90AA1 (0.61) | HSP90AA1TUBB4ATUBBTUBA3CTUBA1B | |
| SCHEMBL14246782 | 0.77 | MAPT (0.45) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL28659814 | 0.76 | HSP90AA1 (0.49) | MAPTALDH1A1HSD17B10CYP1A2KMT2A | |
| SCHEMBL7101738 | 0.76 | HSP90AA1 (0.44) | MAPTALDH1A1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL7103621 | 0.76 | MAPT (0.51) | MAPTALDH1A1HSD17B10CYP1A2CYP3A4 | |
| SCHEMBL28674917 | 0.75 | HSP90AA1 (0.48) | MAPTALDH1A1KMT2AHSP90AA1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0827959-B1 | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | disclosed |
| US-5977382-A | Benzo[b]thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| US-5977098-A | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| US-5952513-A | TREATING POSTMENOPAUSAL SYNDROME SUCH AS OSTEOPOROSIS | ELI LILLY AND COMPANY (US) | 1999-09-14 | — | — | US | disclosed |
| US-5843965-A | Benzo B! thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-12-01 | — | — | US | disclosed |
| EP-0827959-A2 | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-03-11 | — | — | EP | disclosed |