Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.43 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | VDR | P11473 | 1/20 | 0.38 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.38 |
| ▸ | TUBB | P07437 | 1/20 | 0.38 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.38 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.38 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7106140 | 0.82 | RAPGEF4 (0.44) | MAPTCYP3A4CYP2C9CYP2C19RAPGEF4 | |
| SCHEMBL7105399 | 0.81 | TUBB4A (0.41) | MAPTCYP3A4CYP2C9CYP2C19RAPGEF4 | |
| SCHEMBL7102544 | 0.76 | MAPT (0.53) | HSP90AA1MAPTCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL7106615 | 0.76 | TUBB4A (0.44) | HSP90AA1MAPTCYP3A4CYP2C9CYP2C19 | |
| SCHEMBL7107446 | 0.76 | ITGA4 (0.44) | MAPTRAPGEF4ALDH1A1L3MBTL1SMN1; SMN2 | |
| SCHEMBL7107233 | 0.74 | HSP90AA1 (0.53) | HSP90AA1MAPTCYP3A4CYP2C19ALDH1A1 | |
| SCHEMBL28659814 | 0.70 | HSP90AA1 (0.49) | HSP90AA1MAPTCYP2C9ALDH1A1L3MBTL1 | |
| SCHEMBL11614468 | 0.69 | L3MBTL1 (0.51) | HSP90AA1MAPTRAPGEF4ALDH1A1L3MBTL1 | |
| SCHEMBL28674917 | 0.69 | HSP90AA1 (0.48) | HSP90AA1MAPTALDH1A1L3MBTL1MEN1 | |
| SCHEMBL7104829 | 0.68 | HSP90AA1 (0.61) | HSP90AA1TUBB4ATUBBTUBA3CTUBA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0827959-B1 | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | LILLY CO ELI (US) | 2003-12-03 | — | — | EP | disclosed |
| US-5977382-A | Benzo[b]thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| US-5977098-A | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1999-11-02 | — | — | US | disclosed |
| US-5952513-A | TREATING POSTMENOPAUSAL SYNDROME SUCH AS OSTEOPOROSIS | ELI LILLY AND COMPANY (US) | 1999-09-14 | — | — | US | disclosed |
| US-5843965-A | Benzo B! thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-12-01 | — | — | US | disclosed |
| EP-0827959-A2 | Benzo[B]thiophene compounds, intermediates, processes, compositions, and methods | ELI LILLY AND COMPANY (US) | 1998-03-11 | — | — | EP | disclosed |