Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 8/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.55 |
| ▸ | NPC1 | O15118 | 2/20 | 0.55 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7097011 | 0.88 | HTT (0.70) | HTTKMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL1499599 | 0.86 | CYP11B2 (0.71) | HTTKMT2AALDH1A1KDM4ENPC1 | |
| SCHEMBL7095414 | 0.84 | HTT (0.73) | HTTKMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL7100225 | 0.82 | HTT (0.70) | HTTKMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL7099136 | 0.82 | HTT (0.70) | HTTKMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL7096937 | 0.82 | HTT (0.73) | HTTKMT2AALDH1A1KDM4ESMN1; SMN2 | |
| SCHEMBL14096398 | 0.79 | RAB9A (0.70) | HTTKMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL14096631 | 0.78 | CYP11B2 (0.53) | KMT2AALDH1A1KDM4ESMN1; SMN2RAB9A | |
| SCHEMBL2865777 | 0.78 | HTT (0.55) | HTTKMT2AALDH1A1SMN1; SMN2RAB9A | |
| SCHEMBL14096372 | 0.77 | NAMPT (0.72) | KMT2AALDH1A1KDM4ESMN1; SMN2RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0878196-B1 | KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES | YAMANOUCHI PHARMA CO LTD (JP) | 2003-09-03 | — | — | EP | disclosed |
| US-6133258-A | PYRIDOTHIAZINE DERIVATIVE; FOR TREATMENT OF AMYOTROPHIC LATERAL SCLEROSIS, MULTIPLE SCLEROSIS, PAIN, GLAUCOMA | YAMANOUCHI PHARMACEUTICAL CO., LTD. (JP) | 2000-10-17 | — | — | US | disclosed |
| EP-0878196-A1 | KAINIC ACID NEURONOTOXICITY INHIBITORS AND PYRIDOTHIAZINE DERIVATIVES | YAMANOUCHI PHARMACEUTICAL CO. LTD. (JP) | 1998-11-18 | — | — | EP | disclosed |