Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 18/20 | 1.00 |
| ▸ | ITGA4 | P13612 | 18/20 | 1.00 |
| ▸ | APP | P05067 | 1/20 | 0.45 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.41 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.41 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.41 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7102732 | 1.00 | ITGB1 (1.00) | ITGB1ITGA4APPPLAAT3PLAAT5 | |
| SCHEMBL7104202 | 0.83 | ITGB1 (1.00) | ITGB1ITGA4 | |
| SCHEMBL7107382 | 0.82 | ITGB1 (0.70) | ITGB1ITGA4 | |
| SCHEMBL7718508 | 0.81 | ITGB1 (0.77) | ITGB1ITGA4APP | |
| SCHEMBL7105093 | 0.79 | ITGB1 (0.65) | ITGB1ITGA4 | |
| SCHEMBL7100060 | 0.79 | ITGA4 (1.00) | ITGB1ITGA4 | |
| SCHEMBL7100066 | 0.79 | ITGA4 (1.00) | ITGB1ITGA4 | |
| SCHEMBL7259731 | 0.79 | ITGB1 (0.65) | ITGB1ITGA4APP | |
| SCHEMBL7259735 | 0.79 | ITGB1 (0.65) | ITGB1ITGA4APP | |
| SCHEMBL7259905 | 0.78 | ITGB1 (0.66) | ITGB1ITGA4APP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20030162799-A1 | Carbocyclic oxo, carboxy amines such as 3-(4-(3,5-Dichloro-4-pyridylcarboxamido)phenyl)-2-(2-propylamino-3,4 -dioxocyclobut-1-enyl)amino)propanoic acid, used as integrin antagonists; antiinflammatory agents | CELLTECH R&D LIMITED (GB) | 2003-08-28 | — | — | US | disclosed |
| US-6518283-B1 | To modify integrin function in such a way as to beneficially modulate cell adhesion | CELLTECH R&D LIMITED (GB) | 2003-02-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030162799-A1 | Carbocyclic oxo, carboxy amines such as 3-(4-(3,5-Dichloro-4-pyridylcarboxamido)phenyl)-2-(2-propylamino-3,4 -dioxocyclobut-1-enyl)amino)propanoic acid, used as integrin antagonists; antiinflammatory agents | ICAM1, VCAM1, CCR1 | ITGB1 5/4885ITGA4 28/4885APP 4031/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.