Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | MEN1 | O00255 | 2/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | CTSL | P07711 | 1/20 | 0.44 |
| ▸ | CTSS | P25774 | 1/20 | 0.44 |
| ▸ | CTSD | P07339 | 1/20 | 0.44 |
| ▸ | PLAAT3 | P53816 | 3/20 | 0.43 |
| ▸ | PLAAT5 | Q96KN8 | 3/20 | 0.43 |
| ▸ | PLAAT2 | Q9NWW9 | 3/20 | 0.43 |
| ▸ | PLAAT4 | Q9UL19 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7104234 | 0.92 | KMT2A (0.50) | KMT2AALDH1A1PLAAT3PLAAT5PLAAT2 | |
| SCHEMBL7103729 | 0.92 | KMT2A (0.53) | KMT2AALDH1A1HPGDCTSDPLAAT3 | |
| SCHEMBL7104047 | 0.91 | KMT2A (0.50) | KMT2AHPGDSMN1; SMN2PLAAT3PLAAT5 | |
| SCHEMBL7098635 | 0.88 | CTSD (0.51) | KMT2AMEN1ALDH1A1SMN1; SMN2CTSD | |
| SCHEMBL7101187 | 0.83 | KMT2A (0.47) | KMT2AMEN1ALDH1A1PLAAT3PLAAT5 | |
| SCHEMBL7102597 | 0.83 | KMT2A (0.47) | KMT2AALDH1A1HPGDL3MBTL1 | |
| SCHEMBL7414343 | 0.83 | CTSD (0.43) | KMT2AMEN1ALDH1A1CTSDL3MBTL1 | |
| SCHEMBL7102822 | 0.82 | KMT2A (0.49) | KMT2AMEN1ALDH1A1HPGDSMN1; SMN2 | |
| SCHEMBL7101476 | 0.80 | L3MBTL1 (0.55) | KMT2AALDH1A1SMN1; SMN2L3MBTL1 | |
| SCHEMBL7162745 | 0.76 | L3MBTL1 (0.51) | KMT2AALDH1A1SMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140818-B1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMA INC (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6329550-B1 | FOR THERAPY OF EMPHYSEMA, OSTEOPOROSIS, RHEUMATOID ARTHRITIS AND NEOPLASTIC DISEASES | AVENTIS PHARMACEUTICALS INC. | 2001-12-11 | — | — | US | disclosed |
| EP-1140818-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | Aventis Pharmaceuticals Inc. (US) | 2001-10-10 | — | — | EP | disclosed |
| WO-2000040552-A1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMACEUTICALS INC. (US) | 2000-07-13 | — | — | WO | disclosed |