Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | CNR2 | P34972 | 13/20 | 0.47 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.39 |
| ▸ | CNR1 | P21554 | 2/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7652101 | 0.83 | KMT2A (0.55) | KMT2ACNR2KDM4E | |
| SCHEMBL7103507 | 0.81 | KMT2A (0.53) | KMT2ACNR2GABRA1CNR1KDM4E | |
| SCHEMBL7107999 | 0.80 | CNR2 (0.44) | KMT2ACNR2GABRA1CNR1KDM4E | |
| SCHEMBL7656385 | 0.78 | KMT2A (0.56) | KMT2ACNR2KDM4E | |
| SCHEMBL8052528 | 0.77 | KMT2A (0.47) | KMT2ACNR2CNR1KDM4E | |
| SCHEMBL18130923 | 0.76 | CNR2 (0.52) | CNR2GABRA1CNR1 | |
| SCHEMBL7656633 | 0.74 | KMT2A (0.45) | KMT2ACNR2KDM4E | |
| SCHEMBL2629263 | 0.72 | NPC1 (0.51) | KMT2AKDM4E | |
| SCHEMBL7105213 | 0.72 | CNR2 (0.39) | CNR2CNR1KDM4E | |
| SCHEMBL6417609 | 0.70 | KDM4E (0.56) | KMT2ACNR2CNR1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | disclosed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |