Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.45 |
| ▸ | DGAT2 | Q96PD7 | 3/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CNR2 | P34972 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7660743 | 0.81 | KDM4E (0.47) | KMT2AKDM4EPTGS2POLBGAA | |
| SCHEMBL7103507 | 0.79 | KMT2A (0.53) | KMT2ADGAT2KDM4ECNR2 | |
| SCHEMBL7575404 | 0.74 | POLB (0.61) | KMT2APOLBGAACYP2C19CYP3A4 | |
| SCHEMBL7103670 | 0.74 | KMT2A (0.55) | KMT2AKDM4ECNR2 | |
| SCHEMBL7652101 | 0.73 | KMT2A (0.55) | KMT2AKDM4EPOLBCNR2ALDH1A1 | |
| SCHEMBL12301905 | 0.73 | ALDH1A1 (0.53) | KMT2APOLBGAAALDH1A1 | |
| SCHEMBL8018921 | 0.72 | LMNA (0.49) | KMT2AKDM4EPTGS2POLBGAA | |
| SCHEMBL2735676 | 0.71 | HCAR2 (0.56) | ATM | |
| SCHEMBL19877014 | 0.71 | NPC1 (0.46) | DGAT2POLBATMCNR2CYP2C9 | |
| SCHEMBL5909197 | 0.71 | THRB (0.61) | KDM4EPTGS2POLBGAAPTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |