Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 5/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 3/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.35 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
| ▸ | JAK3 | P52333 | 2/20 | 0.35 |
| ▸ | SIRT5 | Q9NXA8 | 2/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 3/20 | 0.34 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.34 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | ATM | Q13315 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | FOS | P01100 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7103790 | 0.92 | GSK3B (0.40) | GSK3BMAPTNPC1RAB9AMEN1 | |
| SCHEMBL5099951 | 0.87 | MAPT (0.47) | GSK3BMAPTKDM4ENPC1RAB9A | |
| SCHEMBL5095061 | 0.85 | GSK3B (0.49) | GSK3BMAPTKDM4ENPC1RAB9A | |
| SCHEMBL5098932 | 0.81 | FOS (0.47) | GSK3BMAPTKDM4ENPC1RAB9A | |
| SCHEMBL5092547 | 0.79 | MAPT (0.46) | GSK3BMAPTKDM4ENPC1RAB9A | |
| SCHEMBL7857033 | 0.79 | GSK3B (0.35) | GSK3BMAPTKDM4ENPC1RAB9A | |
| SCHEMBL5089344 | 0.79 | MAPT (0.48) | GSK3BMAPTKDM4ENPC1RAB9A | |
| SCHEMBL5094456 | 0.79 | GSK3B (0.49) | GSK3BMAPTKDM4ENPC1RAB9A | |
| SCHEMBL5092467 | 0.79 | MAPT (0.50) | GSK3BMAPTKDM4ENPC1RAB9A | |
| SCHEMBL5092748 | 0.78 | MAPT (0.45) | GSK3BMAPTKDM4ENPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1317433-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2003-06-11 | — | — | EP | disclosed |
| WO-2002020495-A2 | INHIBITORS OF GLYCOGEN SYNTHASE KINASE 3 | CHIRON CORPORATION (US) | 2002-03-14 | — | — | WO | disclosed |