Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 3/20 | 0.46 |
| ▸ | LTA4H | P09960 | 1/20 | 0.44 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | GPBAR1 | Q8TDU6 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.40 |
| ▸ | COMT | P21964 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.38 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14334208 | 0.83 | RET (0.40) | PDGFRBRETGPBAR1CYP17A1CYP11B1 | |
| SCHEMBL7100910 | 0.82 | GSK3B (0.41) | PDGFRBLTA4HRETCYP17A1CYP11B1 | |
| SCHEMBL6210283 | 0.81 | LTA4H (0.51) | NPC1LTA4HCYP11B1CYP11B2 | |
| SCHEMBL14334743 | 0.77 | RET (0.43) | PDGFRBRETPDGFRA | |
| SCHEMBL14334462 | 0.76 | PDGFRB (0.39) | NPC1PDGFRBRETPDGFRACYP17A1 | |
| SCHEMBL4317092 | 0.74 | CYP17A1 (0.60) | NPC1PDGFRBLTA4HRETGPBAR1 | |
| SCHEMBL10905429 | 0.74 | LTA4H (0.47) | LTA4H | |
| SCHEMBL14334131 | 0.73 | MAPK1 (0.40) | PDGFRBRET | |
| SCHEMBL5758497 | 0.73 | CASP3 (0.49) | NPC1PDGFRBPDGFRA | |
| SCHEMBL11771733 | 0.73 | LTA4H (0.46) | LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2003500357-A | — | — | 2003-01-07 | — | — | JP | claimed |
| EP-1194144-A4 | ANTIBACTERIAL COMPOUNDS | SMITHKLINE BEECHAM CORP (US) | 2002-08-07 | — | — | EP | claimed |
| EP-1194144-A1 | ANTIBACTERIAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2002-04-10 | — | — | EP | claimed |
| WO-2000071120-A1 | ANTIBACTERIAL COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2000-11-30 | — | — | WO | claimed |