SCHEMBL7103868

SCHEMBL7103868

CCOc1cc(NN2CCCC2)cnc1Br

nearest known ligand 0.48

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CHRNB2 P17787 2/20 0.48
CHRNA4 P43681 2/20 0.48
POLB P06746 2/20 0.38
MEN1 O00255 1/20 0.37
RAB9A P51151 1/20 0.37
KMT2A Q03164 1/20 0.37
ALDH1A1 P00352 3/20 0.35
HPGD P15428 1/20 0.35
HSD17B10 Q99714 1/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
GAA P10253 1/20 0.34
KDM4E B2RXH2 1/20 0.33
LMNA P02545 1/20 0.33
MAPT P10636 1/20 0.33
MAPK1 P28482 1/20 0.33
TDP1 Q9NUW8 1/20 0.33
BRD4 O60885 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7097546 0.99 CHRNB2 (0.47) CHRNB2CHRNA4POLBMEN1RAB9A
SCHEMBL7102266 0.99 CHRNB2 (0.47) CHRNB2CHRNA4POLBMEN1RAB9A
SCHEMBL7102444 0.74 FPR3 (0.38) MEN1RAB9AKMT2A
SCHEMBL7100962 0.74 CHRNB2 (0.42) CHRNB2CHRNA4POLBMEN1RAB9A
SCHEMBL7099497 0.73 CHRNB2 (0.41) CHRNB2CHRNA4POLBMEN1RAB9A
SCHEMBL7102609 0.73 FPR3 (0.37) MEN1RAB9AKMT2ASMN1; SMN2KDM4E
SCHEMBL7099156 0.73 FPR3 (0.37) MEN1RAB9AKMT2ASMN1; SMN2KDM4E
SCHEMBL7487600 0.73 CHRNB2 (0.41) CHRNB2CHRNA4POLBMEN1RAB9A
SCHEMBL7101803 0.71 CHRNB2 (0.41) CHRNB2CHRNA4POLBALDH1A1HPGD
SCHEMBL7103730 0.71 CHRNB2 (0.41) CHRNB2CHRNA4POLBALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
JP-2003500402-A 2003-01-07 JP claimed
CN-1361774-A Heterocyclic substituted amino nitrogen heterocycles as central nervous system medicaments ABBOTT INC (US) 2002-07-31 CN claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP claimed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO claimed
EP-1178982-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2002-02-13 EP disclosed
WO-2000071534-A1 HETEROCYCLIC SUBSTITUTED AMINOAZACYCLES USEFUL AS CENTRAL NERVOUS SYSTEM AGENTS ABBOTT LABORATORIES (US) 2000-11-30 WO disclosed