Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 3/20 | 0.57 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.57 |
| ▸ | NQO2 | P16083 | 3/20 | 0.52 |
| ▸ | HTR2C | P28335 | 3/20 | 0.50 |
| ▸ | TAAR1 | Q96RJ0 | 3/20 | 0.50 |
| ▸ | HTR1A | P08908 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 2/20 | 0.50 |
| ▸ | HTR2B | P41595 | 2/20 | 0.50 |
| ▸ | DRD1 | P21728 | 2/20 | 0.50 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.50 |
| ▸ | HTR3B | O95264 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | HTR1D | P28221 | 1/20 | 0.50 |
| ▸ | HTR1B | P28222 | 1/20 | 0.50 |
| ▸ | HTR1E | P28566 | 1/20 | 0.50 |
| ▸ | HTR1F | P30939 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL7245774 | 0.98 | MTNR1A (0.56) | MTNR1AMTNR1BNQO2HTR2CTAAR1 | |
| Hydrochloric Acid SCHEMBL15661933 | 0.98 | MTNR1A (0.56) | MTNR1AMTNR1BNQO2HTR2CTAAR1 | |
| SCHEMBL20198676 | 0.88 | MTNR1A (0.54) | MTNR1AMTNR1BNQO2HTR2CTAAR1 | |
| SCHEMBL12676044 | 0.85 | MTNR1A (0.53) | MTNR1AMTNR1BNQO2TAAR1CYP1A2 | |
| SCHEMBL13523853 | 0.83 | TAAR1 (0.47) | MTNR1AMTNR1BNQO2HTR2CTAAR1 | |
| SCHEMBL14714354 | 0.82 | MTNR1A (0.57) | MTNR1AMTNR1BNQO2CYP1A2HTR5A | |
| SCHEMBL1034405 | 0.81 | MTNR1A (0.55) | MTNR1AMTNR1BNQO2CYP1A2HTR5A | |
| SCHEMBL29281062 | 0.80 | TAAR1 (0.52) | MTNR1AMTNR1BHTR2CTAAR1HTR1A | |
| SCHEMBL26061042 | 0.79 | MTNR1A (0.55) | MTNR1AMTNR1BNQO2HTR2CCYP1A2 | |
| SCHEMBL8020797 | 0.79 | MTNR1A (0.67) | MTNR1AMTNR1BNQO2TRPV1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909166-A1 | PROCESSES FOR THE PREPARATION OF AGOMELATINE USING NOVEL INTERMEDIATES | Symed Labs Limited (IN) | 2015-08-26 | — | — | EP | claimed |
| WO-2014064706-A1 | PROCESSES FOR THE PREPARATION OF AGOMELATINE USING NOVEL INTERMEDIATES | SYMED LABS LIMITED (IN) | 2014-05-01 | — | — | WO | claimed |
| WO-2016046833-A2 | IMPROVED PROCESSES FOR THE PREPARATION OF AGOMELATINE USING NOVEL INTERMEDIATES | SYMED LABS LIMITED (IN) | 2016-03-31 | — | — | WO | disclosed |
| EP-2909166-A1 | PROCESSES FOR THE PREPARATION OF AGOMELATINE USING NOVEL INTERMEDIATES | Symed Labs Limited (IN) | 2015-08-26 | — | — | EP | disclosed |
| WO-2014064706-A1 | PROCESSES FOR THE PREPARATION OF AGOMELATINE USING NOVEL INTERMEDIATES | SYMED LABS LIMITED (IN) | 2014-05-01 | — | — | WO | disclosed |
| WO-2014064706-A1 | PROCESSES FOR THE PREPARATION OF AGOMELATINE USING NOVEL INTERMEDIATES | SYMED LABS LIMITED (IN) | 2014-05-01 | — | — | WO | disclosed |
| EP-1038863-B1 | Substituted dimeric compounds, process for their preparation and pharmaceutical compositions thereof | SERVIER LAB (FR) | 2003-06-04 | — | — | EP | disclosed |
| EP-0708099-B1 | Tricyclic amide compounds, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2001-11-28 | — | — | EP | disclosed |
| EP-1038863-A2 | Substituted dimeric compounds, process for their preparation and pharmaceutical compositions thereof | ADIR ET COMPAGNIE (FR) | 2000-09-27 | — | — | EP | disclosed |
| US-5998461-A | SLEEP DISORDERS | ADIR ET COMPAGNIE (FR) | 1999-12-07 | — | — | US | disclosed |
| US-5843986-A | Tricyclic amide compounds | ADIR ET COMPAGNIE (FR) | 1998-12-01 | — | — | US | disclosed |
| US-5668180-A | MELATONINERGIC SYSTEM FOR CARDIAC ARRHYTHMIA AND ENDOCRINE FUNCTIONS AND CENTRAL NERVOUS SYSTEM FOR ANTIPSYCHOTIC AGENTS | ADIR ET COMPAGNIE (FR) | 1997-09-16 | — | — | US | disclosed |
| EP-0745583-A1 | Alkoxy aryl compounds with affinity to the melatonine receptors, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-12-04 | — | — | EP | disclosed |
| EP-0708099-A1 | Tricyclic amide compounds, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1996-04-24 | — | — | EP | disclosed |
| EP-0562956-B1 | Naphtylalkylamines, process for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1995-09-27 | — | — | EP | disclosed |
| US-5449689-A | Treating melatoninergic system disorders | ADIR ET COMPAGNIE (FR) | 1995-09-12 | — | — | US | disclosed |
| US-5449690-A | Antihypercholesterol anf melatonin antagonist | ADIR ET COMPAGNIE (FR) | 1995-09-12 | — | — | US | disclosed |
| US-5389683-A | Useful in treating or preventing a disorder of the melatoninergic system | ADIR ET COMPAGNIE (FR) | 1995-02-14 | — | — | US | disclosed |
| US-5385944-A | Naphthylethylureas and naphthylethylthioureas | ADIR ET COMPAGNIE (FR) | 1995-01-31 | — | — | US | disclosed |
| EP-0562956-A1 | Naphtylalkylamines, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1993-09-29 | — | — | EP | disclosed |