Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 5/20 | 0.48 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | ASPH | Q12797 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7104026 | 0.88 | MMP13 (0.48) | MMP13SLC22A8KDM4EMAPK1HTT | |
| SCHEMBL6428872 | 0.83 | MMP13 (0.53) | MMP13SLC22A8KDM4ERXFP1ALDH1A1 | |
| SCHEMBL6364247 | 0.83 | MMP13 (0.65) | MMP13SLC22A8ALDH1A1HPGDCYP1A2 | |
| SCHEMBL6295571 | 0.80 | MMP13 (0.56) | MMP13SLC22A8SMN1; SMN2RXFP1TP53 | |
| SCHEMBL6468114 | 0.79 | MMP13 (0.67) | MMP13SLC22A8TP53MAPT | |
| SCHEMBL6256740 | 0.78 | MMP13 (0.51) | MMP13SLC22A8KDM4EMAPK1HTT | |
| SCHEMBL7100732 | 0.76 | PIK3CD (0.51) | MMP13SLC22A8KDM4EMAPK1ALDH1A1 | |
| SCHEMBL7017009 | 0.72 | MAPT (0.51) | KDM4EMAPK1HTTSMN1; SMN2RXFP1 | |
| SCHEMBL8311521 | 0.72 | L3MBTL1 (0.46) | MMP13SLC22A8MAPK1SMN1; SMN2TP53 | |
| SCHEMBL6724659 | 0.71 | PPARG (0.53) | MMP13KDM4ERXFP1ALDH1A1PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368324-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002064572-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | disclosed |