Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP13 | P45452 | 2/20 | 0.45 |
| ▸ | SLC22A8 | Q8TCC7 | 1/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.39 |
| ▸ | HPGD | P15428 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | EGLN3 | Q9H6Z9 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.38 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6428878 | 0.82 | MMP13 (0.49) | MMP13SLC22A8MEN1KMT2ACYP3A4 | |
| SCHEMBL6238392 | 0.82 | MMP13 (0.57) | MMP13SLC22A8MEN1KMT2ACYP3A4 | |
| SCHEMBL6238386 | 0.79 | MMP13 (0.49) | MMP13SLC22A8MEN1KMT2ACYP3A4 | |
| SCHEMBL6235291 | 0.77 | MMP13 (0.58) | MMP13SLC22A8ROCK2 | |
| SCHEMBL7104026 | 0.74 | MMP13 (0.48) | MMP13SLC22A8CYP3A4CYP2C9ALDH1A1 | |
| SCHEMBL6239453 | 0.70 | MEN1 (0.55) | MMP13MEN1KMT2AALDH1A1MAPT | |
| SCHEMBL6237471 | 0.70 | PPARG (0.57) | MEN1KMT2AMAPTRAB9A | |
| SCHEMBL7019551 | 0.70 | PPARG (0.57) | MEN1KMT2AMAPTRAB9A | |
| SCHEMBL6235396 | 0.70 | MEN1 (0.52) | MMP13MEN1KMT2ACYP3A4CYP2C9 | |
| SCHEMBL6236712 | 0.70 | MEN1 (0.52) | MMP13MEN1KMT2ACYP3A4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1368324-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | Warner-Lambert Company LLC (US) | 2003-12-10 | — | — | EP | disclosed |
| WO-2002064572-A1 | QUINAZOLINES AS MMP-13 INHIBITORS | WARNER-LAMBERT COMPANY LLC (US) | 2002-08-22 | — | — | WO | disclosed |