Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAAA | Q02083 | 3/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.49 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.47 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.47 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.47 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.47 |
| ▸ | TLR2 | O60603 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | REN | P00797 | 1/20 | 0.46 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.44 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7104044 | 1.00 | NAAA (0.51) | NAAAHPGDCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7098758 | 0.87 | MMP8 (0.58) | KMT2ACNR2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7098762 | 0.87 | MMP8 (0.58) | KMT2ACNR2CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7098130 | 0.85 | MME (0.53) | NAAAHPGDCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7098126 | 0.85 | MME (0.53) | NAAAHPGDCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7104103 | 0.84 | NAAA (0.48) | NAAAHPGDCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7104110 | 0.84 | NAAA (0.48) | NAAAHPGDCHRNB2CHRNB4CHRNA3 | |
| SCHEMBL7101423 | 0.84 | KMT2A (0.51) | KMT2AMEN1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7101421 | 0.84 | KMT2A (0.51) | KMT2AMEN1CYP2D6CYP2C9CYP2C19 | |
| SCHEMBL7102726 | 0.81 | MMP8 (0.54) | KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1140818-B1 | AMIDOMALONAMIDES AND THEIR USE AS INHIBITORS OF MATRIX METALLOPROTEINASE | AVENTIS PHARMA INC (US) | 2003-09-10 | — | — | EP | disclosed |
| US-6329550-B1 | FOR THERAPY OF EMPHYSEMA, OSTEOPOROSIS, RHEUMATOID ARTHRITIS AND NEOPLASTIC DISEASES | AVENTIS PHARMACEUTICALS INC. | 2001-12-11 | — | — | US | disclosed |