Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARG | P37231 | 14/20 | 0.60 |
| ▸ | RXRA | P19793 | 5/20 | 0.57 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | DRD1 | P21728 | 1/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.44 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.44 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.44 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.44 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.44 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.44 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.44 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.44 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8150043 | 0.90 | PPARG (0.72) | PPARGRXRAEGFRCYP1A2ADORA3 | |
| SCHEMBL8150041 | 0.90 | PPARG (0.72) | PPARGRXRAEGFRCYP1A2ADORA3 | |
| SCHEMBL7147839 | 0.90 | PPARG (0.72) | PPARGRXRAEGFRCYP1A2ADORA3 | |
| SCHEMBL8151007 | 0.88 | PPARG (0.60) | PPARGRXRAEGFRCYP1A2ADORA3 | |
| SCHEMBL8151005 | 0.88 | PPARG (0.60) | PPARGRXRAEGFRCYP1A2ADORA3 | |
| SCHEMBL8150999 | 0.88 | PPARG (0.60) | PPARGRXRAEGFRCYP1A2ADORA3 | |
| SCHEMBL7903410 | 0.85 | PPARG (0.54) | PPARGRXRA | |
| SCHEMBL7149706 | 0.84 | PPARG (0.60) | PPARGRXRAEGFRCYP1A2ADORA3 | |
| SCHEMBL24101432 | 0.84 | PPARG (0.67) | PPARGRXRAEGFRCYP1A2ADORA3 | |
| SCHEMBL8741430 | 0.82 | RXRA (0.53) | PPARGRXRACYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0769940-B1 | INDENE sPLA2 INHIBITORS | LILLY CO ELI (US) | 2003-09-17 | — | — | EP | disclosed |
| US-6214876-B1 | PHOSPHOLIPASE INHIBITORS | ELI LILLY AND COMPANY | 2001-04-10 | — | — | US | disclosed |
| EP-0769940-A4 | — | — | 1997-06-11 | — | — | EP | disclosed |
| EP-0769940-A1 | INDENE sPLA 2? INHIBITORS | ELI LILLY AND COMPANY (US) | 1997-05-02 | — | — | EP | disclosed |
| WO-1996003120-A1 | INDENE sPLA2 INHIBITORS | ELI LILLY AND COMPANY (US) | 1996-02-08 | — | — | WO | disclosed |