Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.62 |
| ▸ | NPC1 | O15118 | 4/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | DDX3X | O00571 | 4/20 | 0.62 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.59 |
| ▸ | ITGB1 | P05556 | 9/20 | 0.56 |
| ▸ | ITGA4 | P13612 | 8/20 | 0.56 |
| ▸ | GHSR | Q92847 | 1/20 | 0.55 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.53 |
| ▸ | ITGAV | P06756 | 1/20 | 0.53 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.53 |
| ▸ | KDR | P35968 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14561170 | 0.88 | RAB9A (0.67) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL7100059 | 0.86 | RAB9A (0.61) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL5683215 | 0.86 | DDX3X (0.65) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL29612679 | 0.85 | ITGB1 (0.67) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL3485567 | 0.85 | ITGB1 (0.67) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL8231040 | 0.85 | ITGB1 (0.61) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL14500971 | 0.85 | RAB9A (0.59) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL14561103 | 0.84 | ITGB1 (0.60) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL5679800 | 0.84 | KMT2A (0.65) | RAB9ANPC1MAPTKMT2AMEN1 | |
| SCHEMBL20808405 | 0.84 | ITGB1 (0.59) | RAB9ANPC1MAPTKMT2AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1183241-B1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | AVENTIS PHARMA GMBH (DE) | 2003-09-17 | — | — | EP | disclosed |
| US-6399643-B1 | ANTIINFLAMMATORY AGENTS; ANTIARTHRITIC AGENTS | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2002-06-04 | — | — | US | disclosed |
| EP-1183241-A1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | Aventis Pharma Deutschland GmbH (DE) | 2002-03-06 | — | — | EP | disclosed |
| WO-2000069831-A1 | SPIROIMIDAZOLIDINE DERIVATIVES, THEIR PREPARATION, THEIR USE AND PHARMACEUTICAL PREPARATIONS COMPRISING THEM | AVENTIS PHARMA DEUTSCHLAND GMBH (DE) | 2000-11-23 | — | — | WO | disclosed |