Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | TRPV3 | Q8NET8 | 1/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7656428 | 0.82 | HTT (0.37) | CYP1A2CD274 | |
| SCHEMBL7107275 | 0.80 | LATS1 (0.33) | TRPV3 | |
| SCHEMBL7105302 | 0.78 | HTT (0.40) | — | |
| SCHEMBL7655866 | 0.72 | HTT (0.34) | CD274 | |
| SCHEMBL10246697 | 0.71 | CYP1A2 (0.40) | CYP1A2 | |
| SCHEMBL6132599 | 0.67 | HTT (0.50) | — | |
| SCHEMBL4075711 | 0.63 | — | — | |
| SCHEMBL13090073 | 0.62 | HDAC3 (0.42) | CYP1A2 | |
| SCHEMBL7103793 | 0.62 | NUDT1 (0.33) | — | |
| SCHEMBL16476543 | 0.62 | HTT (0.67) | CYP1A2CD274 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |