Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | PDCD1 | Q15116 | 2/20 | 0.31 |
| ▸ | CD274 | Q9NZQ7 | 2/20 | 0.31 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.30 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.30 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.30 |
| ▸ | LATS1 | O95835 | 1/20 | 0.30 |
| ▸ | LATS2 | Q9NRM7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7663602 | 0.80 | HTT (0.46) | HTTPDCD1CD274 | |
| SCHEMBL7107275 | 0.77 | LATS1 (0.33) | SLC2A1LATS1LATS2 | |
| SCHEMBL6132599 | 0.72 | HTT (0.50) | HTTKMT2ASMN1; SMN2 | |
| SCHEMBL7104686 | 0.72 | CYP1A2 (0.33) | CD274 | |
| SCHEMBL7656428 | 0.72 | HTT (0.37) | HTTKMT2APDCD1CD274 | |
| SCHEMBL17886903 | 0.69 | CYP11B1 (0.40) | CYP11B1CYP11B2 | |
| SCHEMBL21278561 | 0.68 | CYP2A6 (0.41) | CYP11B1CYP11B2 | |
| SCHEMBL10682965 | 0.68 | SLC2A1 (0.40) | HTTKMT2APDCD1CD274SLC2A1 | |
| SCHEMBL7655472 | 0.68 | RIPK1 (0.32) | KMT2A | |
| Hydrochloric Acid SCHEMBL10679660 | 0.67 | HTT (0.41) | HTTKMT2APDCD1CD274SLC2A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |