Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | GAA | P10253 | 3/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11821722 | 0.83 | MAPT (0.53) | LMNATSHRTDP1ALDH1A1KDM4E | |
| SCHEMBL1855195 | 0.80 | KMT2A (0.43) | LMNAALDH1A1KDM4EGAAKMT2A | |
| SCHEMBL30317990 | 0.80 | TSHR (0.59) | LMNATSHRTDP1ALDH1A1KDM4E | |
| SCHEMBL10046438 | 0.80 | TSHR (0.59) | LMNATSHRTDP1ALDH1A1KDM4E | |
| SCHEMBL23123761 | 0.79 | LMNA (0.54) | LMNATSHRTDP1ALDH1A1KDM4E | |
| SCHEMBL346691 | 0.77 | LMNA (0.59) | LMNATSHRTDP1ALDH1A1KDM4E | |
| SCHEMBL21821870 | 0.77 | LMNA (0.47) | LMNATSHRTDP1ALDH1A1KDM4E | |
| SCHEMBL29582015 | 0.77 | LMNA (0.47) | LMNATSHRTDP1ALDH1A1KDM4E | |
| SCHEMBL25268423 | 0.76 | ALDH1A1 (0.46) | LMNATSHRALDH1A1KMT2AMEN1 | |
| SCHEMBL23123610 | 0.76 | CHRNB4 (0.59) | LMNATSHRTDP1ALDH1A1KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6649613-B1 | Integrin inhibitors | MERCK PATENT GMBH (DE) | 2003-11-18 | — | — | US | disclosed |
| EP-1194401-B1 | DIACYLHYDRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2003-09-10 | — | — | EP | disclosed |
| EP-1194401-A1 | DIACYLHYDRAZINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001005753-A1 | DIACYLHYDRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-01-25 | — | — | WO | disclosed |