Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 13/20 | 0.59 |
| ▸ | DRD3 | P35462 | 7/20 | 0.59 |
| ▸ | DRD4 | P21917 | 5/20 | 0.49 |
| ▸ | DRD1 | P21728 | 4/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.49 |
| ▸ | THPO | P40225 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.48 |
| ▸ | HTR1A | P08908 | 3/20 | 0.48 |
| ▸ | HTR7 | P34969 | 3/20 | 0.48 |
| ▸ | DRD5 | P21918 | 1/20 | 0.45 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7020915 | 0.83 | DRD2 (0.59) | DRD2DRD3DRD4DRD1CYP1A2 | |
| SCHEMBL7029720 | 0.83 | DRD2 (0.68) | DRD2DRD3DRD4DRD1CYP1A2 | |
| SCHEMBL7022473 | 0.83 | DRD2 (0.59) | DRD2DRD3DRD4DRD1CYP1A2 | |
| SCHEMBL7024427 | 0.83 | DRD2 (0.68) | DRD2DRD3DRD4DRD1CYP1A2 | |
| SCHEMBL7026910 | 0.80 | DRD2 (0.84) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL7022890 | 0.80 | DRD2 (0.84) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL6820464 | 0.78 | DRD2 (0.57) | DRD2DRD3DRD4DRD1CYP1A2 | |
| SCHEMBL7030804 | 0.77 | DRD2 (0.56) | DRD2DRD3DRD4DRD1CYP1A2 | |
| SCHEMBL7025402 | 0.77 | DRD2 (0.56) | DRD2DRD3DRD4DRD1CYP1A2 | |
| SCHEMBL7328502 | 0.76 | DRD2 (0.61) | DRD2DRD3DRD4DRD1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888319-B1 | SUBSTITUTED 1,2,3,4-TETRAHYDRONAPHTHALENE DERIVATIVES | ASTRAZENECA AB (SE) | 2003-01-29 | — | — | EP | disclosed |