Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.67 |
| ▸ | RAB9A | P51151 | 7/20 | 0.67 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.67 |
| ▸ | NPC1 | O15118 | 5/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | TP53 | P04637 | 5/20 | 0.61 |
| ▸ | MAPT | P10636 | 12/20 | 0.58 |
| ▸ | LMNA | P02545 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 3/20 | 0.57 |
| ▸ | NFKB1 | P19838 | 3/20 | 0.57 |
| ▸ | NFKB2 | Q00653 | 3/20 | 0.57 |
| ▸ | RELA | Q04206 | 3/20 | 0.57 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.56 |
| ▸ | MEN1 | O00255 | 3/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.55 |
| ▸ | PKM | P14618 | 1/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2139503 | 0.88 | RAB9A (0.67) | SMN1; SMN2RAB9AKDM4ENPC1GAA | |
| SCHEMBL16141213 | 0.85 | RAB9A (0.63) | SMN1; SMN2RAB9AKDM4ENPC1GAA | |
| SCHEMBL2247443 | 0.81 | SMN1; SMN2 (1.00) | SMN1; SMN2RAB9AKDM4ENPC1GAA | |
| SCHEMBL12963175 | 0.79 | MAPT (0.75) | SMN1; SMN2RAB9AKDM4ENPC1GAA | |
| SCHEMBL25884715 | 0.79 | SMN1; SMN2 (0.70) | SMN1; SMN2RAB9AKDM4ENPC1GAA | |
| SCHEMBL5461064 | 0.77 | RAB9A (0.77) | SMN1; SMN2RAB9AKDM4ENPC1GAA | |
| SCHEMBL14111242 | 0.76 | MAPT (0.65) | SMN1; SMN2RAB9AKDM4ENPC1GAA | |
| SCHEMBL17059020 | 0.76 | KDM4E (0.64) | SMN1; SMN2RAB9AKDM4ENPC1GAA | |
| SCHEMBL15786286 | 0.76 | KDM4E (0.64) | SMN1; SMN2RAB9AKDM4ENPC1GAA | |
| SCHEMBL25312538 | 0.75 | SMN1; SMN2 (0.62) | SMN1; SMN2RAB9AKDM4ENPC1GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0812319-B9 | 2-ARYLBENZAZOLE COMPOUNDS | CANCER RES VENTURES LTD (GB) | 2003-10-08 | — | — | EP | claimed |
| EP-0812319-B1 | 2-ARYLBENZAZOLE COMPOUNDS | CANCER RES VENTURES LTD (GB) | 2002-07-10 | — | — | EP | claimed |
| US-6034246-A | ANTICANCER AGENT | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-03-07 | — | — | US | claimed |
| EP-0812319-B9 | 2-ARYLBENZAZOLE COMPOUNDS | CANCER RES VENTURES LTD (GB) | 2003-10-08 | — | — | EP | disclosed |
| EP-0812319-B1 | 2-ARYLBENZAZOLE COMPOUNDS | CANCER RES VENTURES LTD (GB) | 2002-07-10 | — | — | EP | disclosed |
| US-6034246-A | ANTICANCER AGENT | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 2000-03-07 | — | — | US | disclosed |