SCHEMBL7105263

SCHEMBL7105263

NC[C@@H](O)C(=O)Oc1ccccc1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ATM Q13315 2/20 0.46
L3MBTL1 Q9Y468 2/20 0.46
ALOX15 P16050 2/20 0.44
ADRB2 P07550 1/20 0.43
ADRB1 P08588 1/20 0.43
ADRB3 P13945 1/20 0.43
ELANE P08246 1/20 0.42
TDP1 Q9NUW8 1/20 0.40
SLC1A3 P43003 1/20 0.40
HTR2A P28223 1/20 0.40
TAAR1 Q96RJ0 1/20 0.40
ADRA2C P18825 1/20 0.39
HPGD P15428 1/20 0.39
HSD17B10 Q99714 1/20 0.39
GABBR2 O75899 1/20 0.39
GABBR1 Q9UBS5 1/20 0.39
ALDH1A1 P00352 1/20 0.39
CYP19A1 P11511 1/20 0.39
MAPT P10636 1/20 0.38
CYP1A2 P05177 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1140159 1.00 ATM (0.46) ATML3MBTL1ALOX15ADRB2ADRB1
SCHEMBL27660502 0.85 ATM (0.44) ATML3MBTL1ALOX15ADRB2ADRB1
SCHEMBL5198959 0.82 ATM (0.47) ATML3MBTL1ALOX15ADRB2ADRB1
SCHEMBL27551102 0.81 ATM (0.46) ATML3MBTL1ALOX15ELANETDP1
SCHEMBL29163224 0.81 ATM (0.46) ATML3MBTL1ALOX15ADRB2ADRB1
SCHEMBL24530374 0.81 ATM (0.46) ATML3MBTL1ALOX15ELANETDP1
SCHEMBL2619547 0.81 ATM (0.50) ATML3MBTL1ADRB2ADRB1ADRB3
SCHEMBL27639690 0.81 ATM (0.46) ATML3MBTL1ALOX15ELANETDP1
SCHEMBL15156036 0.80 CCNC (0.46) ALOX15TDP1HPGDHSD17B10ALDH1A1
SCHEMBL6182569 0.79 CYP1A2 (0.47) ATML3MBTL1ADRB2ADRB1ADRB3

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0847393-B1 PACLITAXEL SYNTHESIS FROM PRECURSOR COMPOUNDS AND METHODS OF PRODUCING THE SAME NAPRO BIOTHERAPEUTICS INC (US) 2003-10-01 EP disclosed
EP-0832080-B9 PACLITAXEL SYNTHESIS FROM PRECURSOR COMPOUNDS AND METHODS OF PRODUCING THE SAME NAPRO BIOTHERAPEUTICS INC (US) 2002-04-17 EP disclosed
EP-0832080-B1 PACLITAXEL SYNTHESIS FROM PRECURSOR COMPOUNDS AND METHODS OF PRODUCING THE SAME NAPRO BIOTHERAPEUTICS INC (US) 2001-11-28 EP disclosed
EP-0837846-B1 C-2' HYDROXYL-BENZYL PROTECTED, N-CARBAMATE PROTECTED (2R,3S)-3-PHENYLISOSERINE AND PRODUCTION PROCESS THEREFOR NAPRO BIOTHERAPEUTICS INC (US) 2001-11-07 EP disclosed
US-5948919-A Paclitaxel synthesis from precursor compounds and methods of producing the same NAPRO BIOTHERAPEUTICS, INC. (US) 1999-09-07 US disclosed
EP-0847393-A4 1998-07-08 EP disclosed
EP-0847393-A1 PACLITAXEL SYNTHESIS FROM PRECURSOR COMPOUNDS AND METHODS OF PRODUCING THE SAME NAPRO BIOTHERAPEUTICS, INC. (US) 1998-06-17 EP disclosed
EP-0832080-A4 1998-04-29 EP disclosed
EP-0832080-A1 PACLITAXEL SYNTHESIS FROM PRECURSOR COMPOUNDS AND METHODS OF PRODUCING THE SAME NAPRO BIOTHERAPEUTICS, INC. (US) 1998-04-01 EP disclosed
US-5684175-A C-2' hydroxyl-benzyl protected, N-carbamate protected (2R, 3S)- 3-phenylisoserine and production process therefor NAPRO BIOTHERAPEUTICS, INC. (US) 1997-11-04 US disclosed
US-5675025-A Paclitaxel synthesis from precursor compounds and methods of producing the same NAPRO BIOTHERAPEUTICS, INC. (US) 1997-10-07 US disclosed
WO-1996040666-A1 PACLITAXEL SYNTHESIS FROM PRECURSOR COMPOUNDS AND METHODS OF PRODUCING THE SAME NAPRO BIOTHERAPEUTICS, INC. (US) 1996-12-19 WO disclosed
WO-1996040667-A1 PACLITAXEL SYNTHESIS FROM PRECURSOR COMPOUNDS AND METHODS OF PRODUCING THE SAME NAPRO BIOTHERAPEUTICS, INC. (US) 1996-12-19 WO disclosed