Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB3 | P05106 | 9/20 | 0.51 |
| ▸ | ITGAV | P06756 | 9/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | GAA | P10253 | 2/20 | 0.46 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.46 |
| ▸ | BLM | P54132 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7099030 | 0.91 | ITGB3 (0.52) | ITGB3ITGAVPOLBCYP1A2CYP3A4 | |
| SCHEMBL7262415 | 0.87 | ITGB3 (0.52) | ITGB3ITGAVPOLBCYP1A2CYP3A4 | |
| SCHEMBL7106602 | 0.82 | ITGB3 (0.67) | ITGB3ITGAVLMNAITGA2BSMN1; SMN2 | |
| SCHEMBL7098481 | 0.82 | ITGB3 (0.67) | ITGB3ITGAVKMT2AITGA2BSMN1; SMN2 | |
| SCHEMBL7099691 | 0.82 | ITGB3 (0.67) | ITGB3ITGAVMEN1KMT2AITGA2B | |
| SCHEMBL7098907 | 0.82 | ITGB3 (0.67) | ITGB3ITGAVKMT2AITGA2BSMN1; SMN2 | |
| SCHEMBL7103918 | 0.82 | ITGB3 (0.67) | ITGB3ITGAVITGA2B | |
| SCHEMBL7104776 | 0.80 | ITGB3 (0.68) | ITGB3ITGAVPOLBITGA2BALDH1A1 | |
| SCHEMBL7099298 | 0.78 | ITGB3 (0.66) | ITGB3ITGAVITGA2BSMN1; SMN2 | |
| SCHEMBL7099027 | 0.77 | KDM4E (0.47) | ITGB3ITGAVPOLBLMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1194401-B1 | DIACYLHYDRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2003-09-10 | — | — | EP | disclosed |
| EP-1194401-A1 | DIACYLHYDRAZINE DERIVATIVES | MERCK PATENT GmbH (DE) | 2002-04-10 | — | — | EP | disclosed |
| WO-2001005753-A1 | DIACYLHYDRAZINE DERIVATIVES | MERCK PATENT GMBH (DE) | 2001-01-25 | — | — | WO | disclosed |