Bromide

Bromide

SCHEMBL7106052

C[S+](C)Cc1ccccc1.[Br-]

nearest known ligand 0.46

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1

The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TP53 P04637 1/20 0.46
ALDH1A1 P00352 4/20 0.44
KDM4E B2RXH2 2/20 0.44
TDP1 Q9NUW8 1/20 0.44
CALM1 P0DP23 1/20 0.43
TSHR P16473 4/20 0.40
IDO1 P14902 1/20 0.39
LOXL2 Q9Y4K0 1/20 0.39
TRPA1 O75762 1/20 0.39
CYP3A4 P08684 1/20 0.39
MAPT P10636 1/20 0.39
MAOB P27338 1/20 0.38
HPGD P15428 1/20 0.38
ALOX15 P16050 1/20 0.38
ALOX12 P18054 1/20 0.38
CASP1 P29466 1/20 0.38
HSD17B10 Q99714 1/20 0.38
TAAR1 Q96RJ0 3/20 0.37
MAOA P21397 1/20 0.37
SLC6A2 P23975 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1109607 0.97 TP53 (0.48) TP53ALDH1A1KDM4ETDP1CALM1
Fluoride Ion SCHEMBL10938266 0.94 TP53 (0.46) TP53ALDH1A1KDM4ETDP1CALM1
Hydrochloric Acid SCHEMBL968647 0.94 ALDH1A1 (0.50) TP53ALDH1A1KDM4ETDP1CALM1
Water SCHEMBL3190778 0.94 TP53 (0.46) TP53ALDH1A1KDM4ETDP1CALM1
Iodide SCHEMBL10884304 0.94 TP53 (0.46) TP53ALDH1A1KDM4ETDP1CALM1
SCHEMBL29441851 0.87 TP53 (0.40) TP53ALDH1A1KDM4ETDP1CALM1
SCHEMBL8757718 0.87 TP53 (0.40) TP53ALDH1A1KDM4ETDP1CALM1
SCHEMBL1135134 0.84 TP53 (0.37) TP53ALDH1A1KDM4ETDP1CALM1
Phosphoric Acid SCHEMBL11528106 0.84 TSHR (0.38) TP53ALDH1A1KDM4ETDP1TSHR
Bromide SCHEMBL1046180 0.83 TP53 (0.46) TP53ALDH1A1KDM4ETDP1CALM1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0974595-B1 PROCESS FOR PRODUCING BORON COMPOUNDS SHOWA DENKO KK (JP) 2003-10-01 EP disclosed
EP-0922708-B1 Production method of borate compounds SHOWA DENKO KK (JP) 2003-05-14 EP disclosed
US-6140537-A REACTING AN ORGANIC OXYBORON COMPOUND WITH LITHIUM, MAGNESIUM, OR COMPOUND THEREOF; FORMING BORON ANION COMPOUND; ION EXCHANGING SHOWA DENKO K.K. (JP) 2000-10-31 US disclosed
EP-0974595-A1 PROCESS FOR PRODUCING BORON COMPOUNDS Showa Denko Kabushiki Kaisha (JP) 2000-01-26 EP disclosed
US-6002044-A REACTING A LITHIUM OR MAGNEISIUM, A HALIDE AND A BORONATE PRECURSOR OBTAINED IN A FIRSST SIMILAR STEP USING A BORIDE; ADDING AN ONIIUM HALIDE TO THE METAL BORATE; PURITY SHOWA DENKO K.K. (JP) 1999-12-14 US disclosed
EP-0922708-A2 Production method of borate compounds SHOWA DENKO KABUSHIKI KAISHA (JP) 1999-06-16 EP disclosed