Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.44 |
| ▸ | JUND | P17535 | 1/20 | 0.43 |
| ▸ | FOSB | P53539 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.42 |
| ▸ | FYN | P06241 | 2/20 | 0.41 |
| ▸ | HTR1A | P08908 | 2/20 | 0.40 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.38 |
| ▸ | CDK9 | P50750 | 5/20 | 0.38 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | SI | P14410 | 1/20 | 0.36 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7967919 | 0.76 | JUND (0.39) | JUNDFOSBHTR2CHTR2AHTR1A | |
| SCHEMBL26811323 | 0.73 | HTR2A (0.50) | JUNDFOSBHTR2CHTR2A | |
| SCHEMBL24330092 | 0.72 | HTR1A (0.41) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL24329831 | 0.71 | JUND (0.52) | JUNDFOSBHTR2CFYNHTR1A | |
| Hydrochloric Acid SCHEMBL26911829 | 0.70 | HTR2C (0.51) | JUNDFOSBHTR2CFYNHTR1A | |
| SCHEMBL5584542 | 0.70 | HTR2C (0.73) | HTR2CHTR1ASLC6A2SLC6A4SLC6A3 | |
| SCHEMBL26811325 | 0.69 | HTR2A (0.45) | HTR2CHTR2ACCNT1CDK9 | |
| Acetic Acid SCHEMBL7965027 | 0.68 | HTR2C (0.41) | HTR2CFYN | |
| SCHEMBL17837929 | 0.68 | FYN (0.45) | HTR2CFYNHTR1ASLC6A2SLC6A4 | |
| SCHEMBL196440 | 0.67 | MGAM (0.55) | MGAMGAASIMGAM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1355904-A2 | HETEROCYCLINDAZOLE AND AZAINDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | Wyeth (US) | 2003-10-29 | — | — | EP | disclosed |
| WO-2002051837-A2 | HETEROCYCLINDAZOLE AND AZAINDAZOLE COMPOUNDS AS 5-HYDROXYTRYPTAMINE-6 LIGANDS | WYETH (US) | 2002-07-04 | — | — | WO | disclosed |