Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.48 |
| ▸ | BCHE | P06276 | 1/20 | 0.69 |
| ▸ | GAA | P10253 | 1/20 | 0.61 |
| ▸ | NPC1 | O15118 | 4/20 | 0.59 |
| ▸ | RAB9A | P51151 | 4/20 | 0.59 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.55 |
| ▸ | DDAH1 | O94760 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.48 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL707879 | 0.97 | BCHE (0.73) | BCHEGAANPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL710645 | 0.94 | BCHE (0.69) | BCHEGAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17200183 | 0.91 | BCHE (0.65) | BCHEGAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL370724 | 0.88 | BCHE (0.86) | BCHEGAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29550341 | 0.88 | BCHE (0.86) | BCHEGAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL29356647 | 0.88 | BCHE (0.69) | BCHEGAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL4963924 | 0.88 | BCHE (0.69) | BCHEGAANPC1RAB9ASMN1; SMN2 | |
| Magnesium SCHEMBL30119882 | 0.87 | BCHE (0.83) | BCHEGAANPC1RAB9ASMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL710081 | 0.84 | BCHE (0.68) | BCHEGAANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL20677810 | 0.83 | BCHE (0.77) | BCHEGAANPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910426-B1 | DIENE POLYMERISATION | INEOS SALES (UK) LTD (GB) | 2018-01-03 | — | — | EP | disclosed |
| US-8124698-B2 | Diene polymerisation | INEOS EUROPE LIMITED (GB) | 2012-02-28 | — | — | US | disclosed |
| US-20100022724-A1 | Diene Polymerisation | INEOS SALES (UK) LIMITED (GB) | 2010-01-28 | — | — | US | disclosed |
| EP-1910426-A1 | DIENE POLYMERISATION | INEOS EUROPE LIMITED (GB) | 2008-04-16 | — | — | EP | disclosed |
| WO-2007015074-A1 | DIENE POLYMERISATION | INEOS EUROPE LIMITED (GB) | 2007-02-08 | — | — | WO | disclosed |