Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM1 known ✓ | P11229 | 1/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.68 |
| ▸ | NPC1 | O15118 | 2/20 | 0.60 |
| ▸ | RAB9A | P51151 | 2/20 | 0.60 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | AR | P10275 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20677805 | 0.97 | BCHE (0.72) | BCHENPC1RAB9AGAAPOLB | |
| SCHEMBL20677810 | 0.89 | BCHE (0.77) | BCHENPC1RAB9AGAAPOLB | |
| SCHEMBL20677816 | 0.85 | BCHE (0.87) | BCHENPC1RAB9AGAAPOLB | |
| SCHEMBL20677807 | 0.85 | BCHE (0.87) | BCHENPC1RAB9AGAAPOLB | |
| Hydrochloric Acid SCHEMBL710080 | 0.84 | BCHE (0.52) | BCHENPC1RAB9AGAAPOLB | |
| Hydrochloric Acid SCHEMBL710646 | 0.84 | BCHE (0.69) | BCHENPC1RAB9AGAAPOLB | |
| SCHEMBL8201381 | 0.82 | BCHE (1.00) | BCHENPC1RAB9AGAAPOLB | |
| Hydrochloric Acid SCHEMBL709235 | 0.81 | BCHE (0.68) | BCHENPC1RAB9APOLBSMN1; SMN2 | |
| SCHEMBL707879 | 0.81 | BCHE (0.73) | BCHENPC1RAB9AGAAPOLB | |
| SCHEMBL6753967 | 0.79 | POLB (0.83) | NPC1RAB9AGAAPOLBAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1910426-B1 | DIENE POLYMERISATION | INEOS SALES (UK) LTD (GB) | 2018-01-03 | — | — | EP | disclosed |
| US-8124698-B2 | Diene polymerisation | INEOS EUROPE LIMITED (GB) | 2012-02-28 | — | — | US | disclosed |
| US-20100022724-A1 | Diene Polymerisation | INEOS SALES (UK) LIMITED (GB) | 2010-01-28 | — | — | US | disclosed |