Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.55 |
| ▸ | MTNR1B | P49286 | 2/20 | 0.55 |
| ▸ | SPR | P35270 | 4/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | IDO1 | P14902 | 1/20 | 0.47 |
| ▸ | HPGD | P15428 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | SNCA | P37840 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HTR2C | P28335 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6075502 | 0.89 | MTNR1A (0.54) | MTNR1AMTNR1BSPRKDM4EALDH1A1 | |
| SCHEMBL5346189 | 0.87 | MTNR1A (0.71) | MTNR1AMTNR1BSPRKDM4EALDH1A1 | |
| SCHEMBL8158265 | 0.84 | MTNR1A (0.78) | MTNR1AMTNR1BKDM4EALDH1A1CYP2D6 | |
| SCHEMBL25030267 | 0.84 | KDM4E (0.58) | MTNR1AMTNR1BSPRKDM4EALDH1A1 | |
| SCHEMBL6075355 | 0.81 | MTNR1A (0.51) | MTNR1AMTNR1BSPRKDM4EALDH1A1 | |
| SCHEMBL5339908 | 0.80 | SPR (0.65) | MTNR1AMTNR1BSPRKDM4EALDH1A1 | |
| SCHEMBL5340014 | 0.79 | MEN1 (0.60) | MTNR1AMTNR1BALDH1A1SNCATRPV1 | |
| SCHEMBL7019870 | 0.79 | TRPV1 (0.68) | MTNR1AMTNR1BMAPTTRPV1MEN1 | |
| SCHEMBL6076414 | 0.78 | SPR (0.60) | MTNR1AMTNR1BSPRKDM4EALDH1A1 | |
| SCHEMBL7100086 | 0.78 | SPR (0.76) | MTNR1ASPRKDM4EALDH1A1NPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1057826-B1 | Substituted dimeric carboxamide derivatives, method for preparing them, and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2003-04-16 | — | — | EP | disclosed |
| US-6310074-B1 | TREATING MELATONINERGIC DISORDERS | ADIR ET COMPAGNIE (FR) | 2001-10-30 | — | — | US | disclosed |
| EP-1057826-A1 | Substituted dimeric carboxamide derivatives, method for preparing them, and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-12-06 | — | — | EP | disclosed |