Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PNP | P00491 | 4/20 | 0.36 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.35 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.35 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.35 |
| ▸ | KCND3 | Q9UK17 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7660448 | 0.83 | PNP (0.37) | PNPKCNA5KCNJ5KCNJ3SCN5A | |
| SCHEMBL7105228 | 0.82 | PNP (0.33) | PNP | |
| SCHEMBL7108600 | 0.81 | TYMP (0.41) | PNPKCNA5KCNJ5KCNJ3SCN5A | |
| SCHEMBL7104647 | 0.81 | PNP (0.32) | PNPKCNA5KCNJ5KCNJ3SCN5A | |
| SCHEMBL7658744 | 0.77 | KCNA5 (0.36) | PNPKCNA5KCNJ5KCNJ3SCN5A | |
| SCHEMBL7663487 | 0.73 | PNP (0.34) | PNPALDH1A1 | |
| SCHEMBL7107256 | 0.70 | BCHE (0.43) | PNPALDH1A1 | |
| SCHEMBL1085808 | 0.69 | LMNA (0.53) | ALDH1A1LMNA | |
| SCHEMBL7107796 | 0.68 | — | — | |
| SCHEMBL7110095 | 0.68 | MTAP (0.34) | PNP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |