Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 2/20 | 0.45 |
| ▸ | CYSLTR1 | Q9Y271 | 2/20 | 0.45 |
| ▸ | PPARA | Q07869 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.40 |
| ▸ | PSEN2 | P49810 | 2/20 | 0.40 |
| ▸ | APH1B | Q8WW43 | 2/20 | 0.40 |
| ▸ | NCSTN | Q92542 | 2/20 | 0.40 |
| ▸ | APH1A | Q96BI3 | 2/20 | 0.40 |
| ▸ | PSENEN | Q9NZ42 | 2/20 | 0.40 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7107421 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1SMN1; SMN2CYSLTR2CYSLTR1 | |
| SCHEMBL7111022 | 1.00 | KDM4E (0.45) | KDM4EALDH1A1SMN1; SMN2CYSLTR2CYSLTR1 | |
| SCHEMBL14501312 | 0.85 | CYSLTR2 (0.59) | KDM4EALDH1A1SMN1; SMN2CYSLTR2CYSLTR1 | |
| SCHEMBL528101 | 0.84 | MAOA (0.49) | KDM4EALDH1A1SMN1; SMN2CYSLTR2CYSLTR1 | |
| SCHEMBL410069 | 0.83 | PSEN1 (0.42) | KDM4EALDH1A1SMN1; SMN2CYSLTR2CYSLTR1 | |
| SCHEMBL8322532 | 0.82 | KDM4E (0.49) | KDM4EALDH1A1SMN1; SMN2CYSLTR2CYSLTR1 | |
| SCHEMBL17024452 | 0.82 | LMNA (0.53) | KDM4EALDH1A1PPARAPPARGPSEN1 | |
| SCHEMBL3175689 | 0.81 | LMNA (0.54) | KDM4EALDH1A1SMN1; SMN2CYSLTR2PPARA | |
| SCHEMBL3175679 | 0.81 | LMNA (0.54) | KDM4EALDH1A1SMN1; SMN2CYSLTR2PPARA | |
| SCHEMBL5047912 | 0.81 | NPC1 (0.43) | KDM4EALDH1A1SMN1; SMN2CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1013639-B1 | Aryl carboxylic acid and tetrazole derivatives comprising a carbamoyloxy unit | HOFFMANN LA ROCHE (CH) | 2003-10-01 | — | — | EP | disclosed |
| US-6335459-B1 | PROSTAGLANDIN I2 RECEPTOR MODULATORS; TREATING TISSUE NECROSIS, PREMATURE UTERINE CONTRACTION, GASTRIC ULCERATION, SEXUAL DYSFUNCTION, MENSTRUAL PAIN AND IMPROPER WOUND HEALING, IMMUNOREGULATION, PLATELET AGGREGATION OR NEUTROPHIL FUNCTION | SYNTEX (U.S.A.) LLC | 2002-01-01 | — | — | US | disclosed |
| EP-1013639-A1 | Aryl carboxylic acid and tetrazole derivatives comprising a carbamoyloxy unit | F. HOFFMANN-LA ROCHE AG (CH) | 2000-06-28 | — | — | EP | disclosed |