Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.48 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.47 |
| ▸ | FEN1 | P39748 | 1/20 | 0.47 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.47 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.44 |
| ▸ | PGR | P06401 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | AGER | Q15109 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | THRB | P10828 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7023021 | 0.88 | ERCC1 (0.48) | TNFERCC1FEN1ERCC4SLC9A1 | |
| SCHEMBL6803416 | 0.79 | TNF (0.60) | TNFERCC1FEN1ERCC4SLC9A1 | |
| SCHEMBL7101330 | 0.76 | ADORA2B (0.40) | ERCC1FEN1ERCC4HDAC1 | |
| SCHEMBL7106149 | 0.76 | GAA (0.43) | THRB | |
| SCHEMBL14692425 | 0.75 | ERCC1 (0.56) | TNFERCC1FEN1ERCC4SLC9A1 | |
| SCHEMBL6510771 | 0.75 | ERCC1 (0.60) | TNFERCC1FEN1ERCC4SLC9A1 | |
| SCHEMBL7852147 | 0.75 | ERCC1 (0.56) | TNFERCC1FEN1ERCC4SLC9A1 | |
| SCHEMBL6363131 | 0.75 | MAPK8 (0.64) | TNFERCC1FEN1ERCC4SLC9A1 | |
| SCHEMBL7021035 | 0.74 | TNF (0.49) | TNFERCC1FEN1ERCC4SLC9A1 | |
| SCHEMBL25936308 | 0.74 | TOP2A (0.58) | TNFERCC1FEN1ERCC4SLC9A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2003089416-A1 | SUBSTITUTED PYRIMIDINE-2,4(1H,3H)-DIONES FOR USE AS MATRIX METALLOPROTEINASE (MMP) INHIBITORS | IBFB GMBH (DE) | 2003-10-30 | — | — | WO | disclosed |
| EP-1357114-A1 | Substituted pyrimidin-2,4(1H,3H)-diones as inhibitors of Matrix Metalloproteinases (MMP) | IBFB GmbH Privates Institut für biomedizinische Forschung und Beratung (DE) | 2003-10-29 | — | — | EP | disclosed |