Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 1/20 | 0.60 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.53 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.53 |
| ▸ | FEN1 | P39748 | 1/20 | 0.53 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.53 |
| ▸ | PGR | P06401 | 2/20 | 0.50 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.49 |
| ▸ | RORA | P35398 | 1/20 | 0.49 |
| ▸ | RORC | P51449 | 1/20 | 0.49 |
| ▸ | RORB | Q92753 | 1/20 | 0.49 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6293988 | 0.88 | KDM4E (0.56) | TNFERCC1FEN1ERCC4PGR | |
| SCHEMBL14560541 | 0.86 | PGR (0.67) | TNFHDAC1ERCC1FEN1ERCC4 | |
| SCHEMBL5036947 | 0.83 | TNF (0.62) | TNFHDAC1ERCC1FEN1ERCC4 | |
| SCHEMBL2858305 | 0.83 | TNF (0.59) | TNFHDAC1ERCC1FEN1ERCC4 | |
| SCHEMBL5037066 | 0.83 | TNF (0.59) | TNFHDAC1ERCC1FEN1ERCC4 | |
| SCHEMBL5033626 | 0.83 | TNF (0.59) | TNFHDAC1ERCC1FEN1ERCC4 | |
| SCHEMBL25936308 | 0.83 | TOP2A (0.58) | TNFHDAC1ERCC1FEN1ERCC4 | |
| SCHEMBL6295236 | 0.82 | MAPK8 (0.55) | PGRRORARORCRORBALDH1A1 | |
| SCHEMBL14692425 | 0.81 | ERCC1 (0.56) | TNFHDAC1ERCC1FEN1ERCC4 | |
| SCHEMBL6510771 | 0.81 | ERCC1 (0.60) | TNFHDAC1ERCC1FEN1ERCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20040259192-A1 | Method for cleaving the human growth hormone gh | IBFB GMBH PRIVATES INSTITUT FUR BIOMEDIZINISCHE FORSCHUNG UND BERATUNG (DE) | 2004-12-23 | — | — | US | claimed |
| WO-2002074945-A1 | METHOD FOR CLEAVING HUMAN GROWTH HORMONE GH | IBFB GMBH PRIVATES INSTITUT FÜR BIOMEDIZINISCHE FORSCHUNG UND BERATUNG (DE) | 2002-09-26 | — | — | WO | claimed |
| US-20040259192-A1 | Method for cleaving the human growth hormone gh | IBFB GMBH PRIVATES INSTITUT FUR BIOMEDIZINISCHE FORSCHUNG UND BERATUNG (DE) | 2004-12-23 | — | — | US | disclosed |
| WO-2002074945-A1 | METHOD FOR CLEAVING HUMAN GROWTH HORMONE GH | IBFB GMBH PRIVATES INSTITUT FÜR BIOMEDIZINISCHE FORSCHUNG UND BERATUNG (DE) | 2002-09-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20040259192-A1 | Method for cleaving the human growth hormone gh | MMP3, MMP25, MMP17 | TNF 475/4885HDAC1 870/4885ERCC1 3579/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.