Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APLNR | P35414 | 1/20 | 0.39 |
| ▸ | ECE1 | P42892 | 3/20 | 0.38 |
| ▸ | MME | P08473 | 1/20 | 0.38 |
| ▸ | ACE | P12821 | 1/20 | 0.38 |
| ▸ | ABCC2 | Q92887 | 1/20 | 0.38 |
| ▸ | EDNRB | P24530 | 1/20 | 0.38 |
| ▸ | EDNRA | P25101 | 1/20 | 0.38 |
| ▸ | GNRHR | P30968 | 1/20 | 0.38 |
| ▸ | ERAP2 | Q6P179 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7107828 | 0.87 | ECE1 (0.38) | ECE1MMEACEEDNRBEDNRA | |
| SCHEMBL7111230 | 0.84 | MME (0.38) | ECE1MMEACEEDNRBEDNRA | |
| SCHEMBL9818557 | 0.80 | PSMB5 (0.50) | MME | |
| SCHEMBL9651627 | 0.80 | PSMB5 (0.50) | MME | |
| SCHEMBL7107780 | 0.80 | ECE1 (0.44) | ECE1MMEACEERAP2 | |
| SCHEMBL7106067 | 0.79 | ITGB1 (0.40) | ECE1MME | |
| SCHEMBL7111472 | 0.78 | ALDH1A1 (0.46) | ECE1MMEERAP2 | |
| SCHEMBL7697199 | 0.77 | MME (0.43) | MMEERAP2 | |
| SCHEMBL31199181 | 0.77 | NTSR2 (0.44) | — | |
| SCHEMBL26508387 | 0.77 | NTSR2 (0.44) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019434-B1 | INHIBITORS OF METALLOPROTEINASES, THEIR THERAPEUTIC USE, AND PROCESS FOR THE PRODUCTION OF THE STARTING COMPOUND IN THEIR SYNTHESIS | POLIFARMA SPA (IT) | 2003-10-01 | — | — | EP | disclosed |
| US-6339160-B1 | FOR THERAPY OF TUMORAL GROWTH AND METASTATIZATION, ATEROSCLEROSIS, MULTIPLE SCLEROSIS, ALZHEIMER'S DISEASE, OSTEOPOROSIS, HYPERTENSION, RHEUMATOID ARTHRITIS AND OTHER INFLAMMATORY DISEASES | POLIFARMA S.P.A. (IT) | 2002-01-15 | — | — | US | disclosed |
| EP-1019434-A2 | INHIBITORS OF METALLOPROTEINASES, THEIR THERAPEUTIC USE, AND PROCESS FOR THE PRODUCTION OF THE STARTING COMPOUND IN THEIR SYNTHESIS | POLIFARMA S.p.A. (IT) | 2000-07-19 | — | — | EP | disclosed |
| WO-1999003878-A2 | INHIBITORS OF METALLOPROTEINASES, THEIR THERAPEUTIC USE, AND PROCESS FOR THE PRODUCTION OF THE STARTING COMPOUND IN THEIR SYNTHESIS | POLIFARMA S.P.A. (IT) | 1999-01-28 | — | — | WO | disclosed |