Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ITGB1 | P05556 | 5/20 | 0.40 |
| ▸ | ITGA4 | P13612 | 5/20 | 0.40 |
| ▸ | TACR1 | P25103 | 1/20 | 0.39 |
| ▸ | MME | P08473 | 1/20 | 0.39 |
| ▸ | ECE1 | P42892 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 3/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8072300 | 0.82 | ITGB1 (0.41) | ITGB1ITGA4MMEECE1CTSK | |
| SCHEMBL7106549 | 0.81 | CTSK (0.48) | ITGB1ITGA4CTSK | |
| SCHEMBL7111230 | 0.79 | MME (0.38) | MMEECE1 | |
| SCHEMBL7107699 | 0.79 | APLNR (0.39) | MMEECE1 | |
| SCHEMBL5683187 | 0.77 | ITGB1 (0.54) | ITGB1ITGA4 | |
| SCHEMBL7107828 | 0.76 | ECE1 (0.38) | MMEECE1 | |
| SCHEMBL7697199 | 0.75 | MME (0.43) | MME | |
| SCHEMBL7110647 | 0.75 | ERAP2 (0.46) | MMEECE1CTSK | |
| SCHEMBL11178329 | 0.75 | CTSK (0.48) | CTSK | |
| SCHEMBL7107780 | 0.74 | ECE1 (0.44) | MMEECE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1019434-B1 | INHIBITORS OF METALLOPROTEINASES, THEIR THERAPEUTIC USE, AND PROCESS FOR THE PRODUCTION OF THE STARTING COMPOUND IN THEIR SYNTHESIS | POLIFARMA SPA (IT) | 2003-10-01 | — | — | EP | disclosed |
| US-6339160-B1 | FOR THERAPY OF TUMORAL GROWTH AND METASTATIZATION, ATEROSCLEROSIS, MULTIPLE SCLEROSIS, ALZHEIMER'S DISEASE, OSTEOPOROSIS, HYPERTENSION, RHEUMATOID ARTHRITIS AND OTHER INFLAMMATORY DISEASES | POLIFARMA S.P.A. (IT) | 2002-01-15 | — | — | US | disclosed |