Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.38 |
| ▸ | CSNK1D | P48730 | 6/20 | 0.38 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.36 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.34 |
| ▸ | FFAR4 | Q5NUL3 | 2/20 | 0.34 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.33 |
| ▸ | PAX8 | Q06710 | 1/20 | 0.33 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6722731 | 0.90 | PTGS2 (0.42) | MAPK14CSNK1DMAPK9MAPK10PTGS2 | |
| SCHEMBL7110955 | 0.90 | MAPK14 (0.36) | MAPK14CSNK1DMAPK9MAPK10PTGS2 | |
| SCHEMBL6730206 | 0.89 | PTGS2 (0.47) | MAPK14CSNK1DMAPK9MAPK10PTGS2 | |
| SCHEMBL6732859 | 0.82 | PTGS2 (0.43) | MAPK14CSNK1DMAPK9MAPK10PTGS2 | |
| SCHEMBL6722938 | 0.82 | PTGS2 (0.39) | MAPK14CSNK1DMAPK9MAPK10PTGS2 | |
| SCHEMBL6721948 | 0.81 | PTGS2 (0.48) | MAPK14CSNK1DMAPK9MAPK10PTGS2 | |
| SCHEMBL6735860 | 0.81 | PTGS2 (0.44) | MAPK14CSNK1DMAPK9MAPK10PTGS2 | |
| SCHEMBL7115446 | 0.81 | BRD4 (0.40) | PTGS2NPSR1MCOLN3 | |
| SCHEMBL6722029 | 0.81 | PTGS2 (0.44) | MAPK14CSNK1DMAPK9MAPK10PTGS2 | |
| SCHEMBL6723710 | 0.81 | PTGS2 (0.45) | MAPK14CSNK1DMAPK9MAPK10PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1296971-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | Pharmacia Corporation (US) | 2003-04-02 | — | — | EP | disclosed |
| WO-2001081332-A2 | 2-FLUOROBENZENESULFONYL COMPOUNDS FOR THE TREATMENT OF INFLAMMATION | PHARMACIA CORPORATION (US) | 2001-11-01 | — | — | WO | disclosed |