Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.53 |
| ▸ | MAOB | P27338 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18130913 | 0.89 | SIRT6 (0.52) | CNR1MAOBNPC1RAB9APOLB | |
| SCHEMBL7103718 | 0.89 | CNR1 (0.52) | CNR1MAOBNPC1RAB9AKDM4E | |
| SCHEMBL10674362 | 0.82 | KDM4E (0.67) | NPC1RAB9AKDM4EPOLBHPGD | |
| SCHEMBL7107993 | 0.81 | SMN1; SMN2 (0.46) | CNR1MAOBNPC1RAB9AKDM4E | |
| SCHEMBL7660982 | 0.81 | POLB (0.56) | MAOBNPC1RAB9AKDM4EPOLB | |
| SCHEMBL19835607 | 0.81 | MAOB (0.76) | MAOBNPC1RAB9APOLBHPGD | |
| SCHEMBL7105040 | 0.79 | HPGD (0.54) | NPC1RAB9AKDM4EPOLBHPGD | |
| SCHEMBL30065409 | 0.79 | KDM4E (0.55) | CNR1MAOBRAB9AKDM4EPOLB | |
| SCHEMBL29314672 | 0.79 | CNR1 (0.51) | CNR1MAOBNPC1RAB9AKDM4E | |
| SCHEMBL10060679 | 0.79 | KDM4E (0.55) | CNR1MAOBRAB9AKDM4EPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1001944-B1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | AVENTIS PHARMA SA (FR) | 2003-10-01 | — | — | EP | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | claimed |
| EP-1001944-A1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | Aventis Pharma S.A. (FR) | 2000-05-24 | — | — | EP | claimed |
| WO-1999003844-A1 | PYRAZINE DERIVATIVES, PREPARATION AND MEDICINES CONTAINING THEM | RHONE-POULENC RORER S.A. (FR) | 1999-01-28 | — | — | WO | claimed |
| US-6399613-B1 | N,N'-BIS(2-HYDROXYETHYL)PYRAZINE-2,5- OR -2,6-DICARBOXAMIDE; DIABETES | AVENTIS PHARMA S.A. (FR) | 2002-06-04 | — | — | US | disclosed |